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You searched on: Author: pawel jaruga

Displaying records 51 to 60 of 64 records.
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51. Identification and Characterization of a Human DNA Glycosylase for Repair of Modified Bases in Oxidatively Damaged DNA
Published: 3/19/2002
Authors: T. K. Hazra, T. Izumi, I Boldough, B Imhoff, Y W Kow, Pawel Jaruga, M Miral Dizdar, Somenath Mitra
Abstract: 8-oxoguanine (8-oxoG), ring-opened purines (formamidopyrimidines or Fapys), and other oxidized DNA base lesions generated by reactive oxygen species, are often mutagenic and toxic, and have been implicated in the etiology of many diseases including c ...

52. Mass Spectrometric Assays for the Tandem Lesion 8,5'- Cyclo-2' Deoxyguanosine in Mammalian DNA
Published: 3/19/2002
Authors: Pawel Jaruga, M Birincioglu, H Rodriguez, M Miral Dizdar
Abstract: 8,5'-Cyclopurine-2'-deoxynucleosides are among major lesions in DNA that are formed by attack of hydroxyl radical. These compounds represent a concomitant damage to both sugar and base moieties of the same nucleoside and thus can be considered tandem ...

53. Chlorella Virus Pyrimidine Dimer Glycosylase Excises Ultraviolet Radiation- and Hydroxyl Radical-Induced Products 4,6-Diamino-5-Formamidopyrimidine and 2,6-Diamino-4-Hydroxy-5-Formamidopyrimidine from DNA
Published: 2/1/2002
Authors: Pawel Jaruga, R Jabil, Amanda K McCullough, H Rodriguez, M Miral Dizdar, R Stephen Lloyd
Abstract: A DNA glycosylase specific for UV radiation-induced pyrimidine dimers has been identified from chlorella virus Paramecium bursaria chlorella virus-1. This enzyme (Chlorella virus Pyrimidine dimer glycosylase [cv-pdgl) exhibits a 41% amino acid identi ...

54. Determination of Active Site Residues in Escherichia Coli Endonuclease VIII
Published: 1/25/2002
Authors: S. M. Burgess, Pawel Jaruga, M L Dodson, M Miral Dizdar, R Stephen Lloyd
Abstract: Endonuclease VIII from Escherichia coli is a DNA glycosylase/lyase that removes oxidatively damaged bases. EndoVIII is a functional homologue of endonuclease III, but a sequence homologue of formamidopyrimidine DNA glycosylase (Fpg). Using multiple ...

55. The Cockayne Syndrome Group B Gene Product is Involved in General Genome Base Excision Repair of 8-hydroxyguanine in DNA
Published: 12/7/2001
Authors: J Tuo, M Muftuoglu, C Chen, Pawel Jaruga, R R Selzer, R M Brosh, H Rodriguez, M Miral Dizdar, V. Bohr
Abstract: Cockayne Syndrome (CS) is a human genetic disorder with two complementation groups, CS-A and CS-B. The CSB gene product is involved in transcription-coupled repair of DNA damage but may participate in other pathways of DNA metabolism. The present s ...

56. Measurement of 8-Hydroxy-2'-Deoxyadenosine In DNA by Liquid Chromatography/Mass Spectrometry
Published: 8/1/2001
Authors: Pawel Jaruga, H Rodriguez, M Miral Dizdar
Abstract: 8-Hydroxyadenine (8-OH-Ade) is one of the major lesions, which is formed in DNA by hydroxyl radical attack on the C-8 position of adenine followed by oxidation. We describe the measurement of the nucleoside form of this compound, 8-hydroxy-2'-deoxyad ...

57. Identification and Quantification of 8,5'-Cyclo-2'-Deoxyadenosine in DNA by Liquid Chromatography/Mass Spectrometry
Published: 4/1/2001
Authors: M. Dizdaroglu, Pawel Jaruga, H Rodriguez
Abstract: Recent studies suggested that 8,5'-cyclo-2'-deoxyadenosine may play a role in diseases with defective nucleotide-excision repair. This compound is one of the major lesions formed in DNA by hydroxyl radical attack on sugar moiety of 2'-deoxyadenosine ...

58. Mechanisms and Measurement of Oxidative Damage to DNA
Published: 3/1/2001
Authors: M. Dizdaroglu, Pawel Jaruga, H Rodriguez
Abstract: Free radicals are produced in cells by normal metabolism and by exogenous sources. These species cause oxidative damage to DNA and generate multiple products including modified bases and sugars, strands breaks and DNA-protein crosslinks by a variety ...

59. Measurement of 8-Hydroxy-2'-Deoxyguanosine in DNA by High-Performance Liquid Chromatography-Mass Spectrometry: Comparison with Measurement by Gas Chromatography-Mass Spectrometry
Published: 2/1/2001
Authors: M. Dizdaroglu, Pawel Jaruga, H Rodriguez
Abstract: Measurement of 8-hydroxy-2'-deoxyguanosine (8-OH-dGuo) in DNA by high-performance liquid chromatography/mass spectrometry (HPLC/MS) was studied. A methodology was developed for separation by LC of 8-OH-dGuo from intact and modified nucleosides i ...

60. Characterization and Mechanism of Action of Drosophila Ribosomal Protein S3 DNA Glycosylase Activity for the Removal of Oxidatively Damaged DNA Bases
Published: 12/26/1997
Authors: W. A. Deutsch, A. Yacoub, Pawel Jaruga, T. H. Zastawny, M Miral Dizdar

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