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The Chemical Sciences Division is helping to support nanotechnology research being conducted throughout NIST by developing and applying methods for the chemical compositional characterization of nanomaterials. Measurement capabilities being developed include the detection and quantification of nanoparticles by way of elemental signatures (for example gold or silver nanoparticles), quantification of other chemicals present in nanomaterial formulations, and techniques to distinguish between free and complexed nanoparticles or to distinguish metals present as nanoparticles from other chemical forms of the metal. The research also includes studies of the behavior of nanoparticles in analytical measurement systems.
NIST has a broad research program spread throughout the major operating units aimed at building the supporting technical capabilities that U.S. industry needs in their quest to develop new nanotech products with desirable new capabilities and bring them safely to market. The Chemical Sciences Division is developing new capabilities to provide chemical compositional characterization of nanomaterials in support of broader NIST nanotechnology research activities including the development of nanomaterial reference materials and the characterization of nanomaterial formulations being developed for cancer treatment. The latter is a collaboration between NIST and the National Cancer Institute’s Nanotechnology Characterization Laboratory.
Additional Technical Details:
We have been collaborating with other NIST divisions to provide chemical compositional measurements of reference materials or other types of samples under investigation. In some cases this has required the development of new methods of analysis or studies of the behavior of nanomaterials in analytical measurement systems. To provide information about the chemical form of specific nanomaterials we have coupled various chromatographic separation techniques with sensitive element-specific detection systems such as inductively coupled plasma mass spectrometry (ICP-MS). We are also developing a system that couples an ion mobility analyzer with ICP-MS as a means of separating metal-containing nanoparticles by size and as a means of distinguishing metals present as nanoparticles from those present as dissolved ions. This type of chemical information is particularly valuable for toxicological studies.
Start Date:January 1, 2006
Lead Organizational Unit:mml
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