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|Author(s):||Fern Y. Hunt; Anthony J. Kearsley; H H Wan;|
|Title:||An Optimization Approach to Multiple Sequence Alignment|
|Published:||July 01, 2003|
|Abstract:||The problem of multiple sequence alignment is recast as an optimization problem using Markov decision theory. One seeks to minimize the expected or average cost of alignment subject to data-derived constraints. In this setting the problem is equivalent to a linear program which can be solved efficiently using modern interior-point methods.|
|Citation:||Applied Mathematics Letters|
|Pages:||pp. 785 - 790|
|Research Areas:||Software, Math, Modeling|
|PDF version:||Click here to retrieve PDF version of paper (494KB)|