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Chemistry Programs & Projects

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NIST SRM for Reproducible Analyses of Single-Walled Carbon Nanotubes
Last Updated Date: 10/16/2012

Carbon nanotubes (CNTs) are one of the first major nanoscale manufactured products to enter the market. Therefore, reliable and reproducible … more

Improved Benchtop Connectivity to Complex Microfluidic Devices
Last Updated Date: 10/10/2012

Despite their promise to enable high-throughput science and discovery, microfluidic devices have not yet been broadly adopted. An important … more

Cell-based Assay for Mechanistically-based Prediction of Cytoxicity
Last Updated Date: 10/10/2012

The most commonly used cell-based assays for measuring cytotoxicity often show poor reproducibility, require 24 h to complete, and rely on a … more

Mercury Vapor Pressure Correlation
Last Updated Date: 10/09/2012

An apparent difference between the historical mercury vapor concentration equations used by the mercury atmospheric measurement community and a … more

Neutron Imaging for Health, Environment, and the Hydrogen Economy
Last Updated Date: 10/09/2012

Quantitative imaging tools enhance our ability to understand biological systems and achieve efficient hydrogen fuel cells. Today's metrological … more

Potential Primary Measurement Tool for the Quantification of DNA
Last Updated Date: 10/09/2012

The accurate mass determination of DNA and other nucleic acids is of critical importance in many clinical diagnoses and in forensic and molecular … more

Study of Microheterogeneity in Solid Reference Materials
Last Updated Date: 10/09/2012

Microbeam X-ray fluorescence (µXRF) has been used nondestructively to investigate elemental heterogeneity by constructing two-dimensional maps of … more

Improving High-Performance Inductively-Coupled Plasma Optical Emission Spectrometry (HP-ICP-OES) Through Exact Matching
Last Updated Date: 10/09/2012

Using high-performance inductively coupled plasma optical emission spectrometry (HP-ICP-OES), relative expanded uncertainties on the order of 0.2 … more

pH Metrology
Last Updated Date: 10/09/2012

The pH metrology program supports traceability for pH measurements. This traceability rests on primary pH measurements in an ideal electrochemical … more

Evaluation of Independent High-Precision Assay Procedures for a High-Purity Primary Standard Reagent
Last Updated Date: 10/09/2012

NIST assigns assay values for a suite of high-purity reagents using two techniques: coulometry and titrimetry. Coulometry is based on Faraday's … more

Molecular Simulation of Stationary Phase Materials in Liquid Chromatography
Last Updated Date: 10/09/2012

Molecular simulation models of monomeric and polymeric stationary phases used for liquid chromatography have been employed to investigate the … more

Comprehensive Two-Dimensional Gas Chromatography/Time of Flight Mass Spectrometry (GC x GC/TOF-MS)
Last Updated Date: 10/09/2012

Although conventional gas chromatography mass spectrometry (GC/MS) provides relatively high efficiency separations, the analysis of some complex, … more

Marine Environmental Metabolomics
Last Updated Date: 10/09/2012

NIST is developing NMR-based metabolomics for use as a tool to expand research on the impacts of environmental stressors on marine organisms. The … more

Novel Stationary Phase Materials in Separation Science Research
Last Updated Date: 10/09/2012

Research activities in separation science continue to focus on investigations of the fundamental physical and chemical processes that influence … more

CCQM Activities in the Organic Analysis Working Group
Last Updated Date: 10/09/2012

NIST's Analytical Chemistry Division has participated in over 50 Consultative Committee for Amount of Substance - Metrology in Chemistry (CCQM) … more

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