Pharmaceuticals

News and Updates

A gloved hand holds a glass flask partly full of pinkish liquid, with a label in marker saying in part "NISTCHO RCB."

NIST, Partners Develop Living Reference Material for Producing Monoclonal Antibodies

January 11, 2023

Publicly available NISTCHO cell line expands the biomanufacturing and research applications of NIST’s monoclonal antibody standard, NISTmAb.

nucleic acid nanotechnology illustration

A Revolution Still in the Making: NIST Researchers Chart the Future of Nucleic Acid Nanotechnology

October 27, 2022

Trapped in a microscopic cage made of strands of DNA, molecules of a life-saving drug course through the bloodstream of a cancer patient. Only when receptors on

NIST Awards Funding to Strengthen Advanced Manufacturing for Microelectronics, Digital and Biomanufacturing

April 1, 2022

GAITHERSBURG, Md. — The U.S. Department of Commerce’s National Institute of Standards and Technology (NIST) has awarded a total of $1.2 million to four

Projects and Programs

Orthogonal Measurements

Ongoing

Reliable measurements of quality attributes of medical products are required for quality control and verification of safety and efficacy. To reduce (i) the risk

AAPS Interlaboratory Study: Protein Aggregation and Immunogenicity

Ongoing

The National Institute of Standards and Technology, in collaboration with the American Association of Pharmaceutical Scientists (AAPS), is coordinating an

Reliable Vaccine Storage

Completed

We study provider-level vaccine storage and temperature monitoring methods to develop best practice guidance for public health audiences.

Fluid Suspensions and Emulsions

Ongoing

The purpose of this project is to create rheological measurement methods and tools, focused on using minimal fluid volumes, to measure local flow dynamics and

Publications

Single-Detector Double-Beam Modulation for High-Sensitivity Infrared Spectroscopy

October 25, 2023

Author(s)

Seongmin Kim, Yow-Ren Chang, Young Jong Lee

Balanced detection based on double beams is widely used to reduce common-mode noises, such as laser intensity fluctuation and irregular wavelength scanning, in

RECENT DEVELOPMENTS IN ONTOLOGY STANDARDS AND THEIR APPLICABILITY TO BIOMANUFACTURING

August 21, 2023

Author(s)

Milos Drobnjakovic, Boonserm Kulvatunyou, Vijay Srinivasan, Simon P. Frechette

ISO and IEC have jointly initiated, and recently issued, a series of standards (the ISO/IEC 21838 series) for top-level ontologies. These standards have been

Letter to the Editor Concerning "Simultaneous, Single-Particle Measurements of Size and Loading Give Insights into the Structure of Drug-Delivery Nanoparticles"

May 23, 2023

Author(s)

Andrew Madison, Adam L. Pintar, Craig R. Copeland, Natalia Farkas, Samuel M. Stavis

Backbone NMR assignment of the yeast produced Fab fragment of the NISTmAb reference antibody

March 1, 2023

Author(s)

Tsega Solomon, Kinlin Chao, Genevieve Gingras, Yves Aubin, William Brad O'Dell, John Marino, Robert Brinson

The monoclonal antibody (mAb) protein class has become a primary therapeutic platform for the production of new life saving drug products. MAbs are comprised of