We demonstrate a prototype approach to formulate gold nanoparticle (AuNP)based Xray absorbing adjuvant agents through surfaceengineering of cisplatin pharmacophore (PtII) with lipoic acidmodified polyacrylate (denoted as PtIIAuNPs). Design of PtIIAuNPs was examined and further validated using a combination of physicochemical characterization methods. Our results show PtIIAuNPs exhibits very high capacity for PtII loading via the mechanism of multidentate coordination between PtII ions and surfacebound polyacrylate. The PtIIAuNP vector presented excellent colloidal stability in an acidsensitive manner that enables PtII drugrelease, and exhibited high in vitro cytotoxicity to the cancer cell lines MCF7 and SKOV3. Secondary electron emissions from both PtII and AuNPs are triggered by an external ionizing radiation source via the Auger cascade. As a result, PtIIAuNPs exhibit therapeutic potential as an adjuvant agent for concurrent chemoradiation cancer therapy.
Pub Type: Journals
gold nanoparticle, cisplatin, cancer therapy, chemo-radiation