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Search Publications by Erdem Coskun

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Displaying 1 - 13 of 13

Recognition of DNA adducts by edited and unedited forms of DNA glycosylase NEIL1

Irina G. Minko, Vladimir Vartanian, Naoto Tozaki, Erdem Coskun, Sanem Hosbas Coskun, Pawel Jaruga, J Yeo, M.P. Stone, M Egli, M Miral Dizdar, Amanda K. McCullough, R S. Lloyd
Pre-mRNA encoding human NEIL1 undergoes editing by adenosine deaminase ADAR1 that converts a single adenosine to inosine, and this conversion results in an

Characterization of Rare NEIL1 Variants Found in East Asian Populations

Irina G. Minko, Vladimir Vartanian, Naoto Tozaki, Oskar Linde, Pawel Jaruga, Sanem Hosbas Coskun, Erdem Coskun, Chunfeng Qu, Huan He, Taoyang Chen, Qianqian Song, Yuchen Jiao, Michael Stone, Martin Egli, M Miral Dizdar, Amanda K. McCullough, R S. Lloyd
The combination of chronic dietary exposure to the fungal toxin, aflatoxin B1 (AFB1), and hepatitis B viral (HBV) infection is associated with an increased risk

Small molecule inhibitors of DNA glycosylases as potential drugs in cancer therapy

M Miral Dizdar, Aaron C. Jacobs, Nathan Donley, Marcus J. Calkins, Ajit Jadhav, Dorjbal Dorjsuren, David Maloney, Anton Simeonov, Pawel Jaruga, Erdem Coskun, Amanda K. McCullough, R. S. Lloyd
Statement of the Problem: Most chemotherapeutic agents kill cancer cells by damaging DNA. Cancer cells overexpress DNA repair proteins and thus increase DNA

Exposure to Engineered Nanomaterials: Impact on DNA Repair Pathways

Neenu Singh, Bryant C. Nelson, Leona D. Scanlan, Erdem Coskun, Pawel Jaruga, Shareen Doak
Some engineered nanomaterials (ENMs) may have the potential to cause damage to the genetic material in living systems. The mechanistic machinery functioning at