Publications

Displaying 1 - 13 of 13

Ion-beam radiation damage to DNA by investigation of free radical formation and base damage

March 1, 2020

Author(s)

Melis Kant, Pawel Jaruga, Erdem Coskun, Samuel Ward, Alexander Stark, David Becker, Amitav Adhikary, Michael Sevilla, M Miral Dizdar

This work investigated the physicochemical processes and DNA base products involved in Ne-22 ion- beam (ca. 1.4 GeV) radiation damage to hydrated (12 waters

Measurement of PARP1 in human tissues by liquid chromatography tandem mass spectrometry

March 1, 2020

Author(s)

Erdem Coskun, Gamze Tuna, Pawel Jaruga, Alessandro Tona, Onur Erdem, M Miral Dizdar

Poly(ADP ribose) polymerase 1 (PARP1) is a multifunctional DNA repair protein of the base excision repair pathway and plays a major role in the repair of DNA

Recognition of DNA adducts by edited and unedited forms of DNA glycosylase NEIL1

November 2, 2019

Author(s)

Irina G. Minko, Vladimir Vartanian, Naoto Tozaki, Erdem Coskun, Sanem Hosbas Coskun, Pawel Jaruga, J Yeo, M.P. Stone, M Egli, M Miral Dizdar, Amanda K. McCullough, R S. Lloyd

Pre-mRNA encoding human NEIL1 undergoes editing by adenosine deaminase ADAR1 that converts a single adenosine to inosine, and this conversion results in an

Characterization of Rare NEIL1 Variants Found in East Asian Populations

May 3, 2019

Author(s)

Irina G. Minko, Vladimir Vartanian, Naoto Tozaki, Oskar Linde, Pawel Jaruga, Sanem Hosbas Coskun, Erdem Coskun, Chunfeng Qu, Huan He, Taoyang Chen, Qianqian Song, Yuchen Jiao, Michael Stone, Martin Egli, M Miral Dizdar, Amanda K. McCullough, R S. Lloyd

The combination of chronic dietary exposure to the fungal toxin, aflatoxin B1 (AFB1), and hepatitis B viral (HBV) infection is associated with an increased risk

Identification and Quantification Of PARP1 in Human Tissues and Cultured Cells by Liquid Chromatography/Isotope-Dilution Tandem Mass Spectrometry

March 10, 2019

Author(s)

Erdem Coskun, Gamze Tuna, Alessandro Tona, Onur Erdem, M Miral Dizdar

Poly(ADP ribose) polymerase 1 (PARP1) is a multifunctional DNA repair protein of the base excision repair pathway and plays a major role in the repair of DNA

Identification and quantification of DNA repair protein poly(ADP ribose) polymerase 1 (PARP1) in human tissues and cultured cells by liquid chromatography/isotope-dilution tandem mass spectrometry

March 1, 2019

Author(s)

Erdem Coskun, Gamze Tuna, Pawel Jaruga, Alessandro Tona, Onur Erdem, M Miral Dizdar

Poly(ADP ribose) polymerase 1 (PARP1) is a multifunctional DNA repair protein of the base excision repair pathway and plays a major role in the repair of DNA

Aflatoxin-guanine DNA Adducts and Oxidatively-induced DNA Damage in Aflatoxin-treated Mice in vivo as Measured by Liquid Chromatography-Tandem Mass Spectrometry with Isotope-dilution

December 11, 2018

Author(s)

Erdem Coskun, Pawel Jaruga, Vladimir Vartanian, Onur Erdem, Patricia Egner, John D. Groopman, R. S. Lloyd, M Miral Dizdar

Dietary exposure to aflatoxin (AFB1) is a significant reason for the incidence of hepatocellular carcinomas globally. AFB1-exposure leads to the formation of

Identification and Quantification of Aflatoxin Guanine and FapyGuanine Adducts in Mouse Liver invivo by LC-MS/MS Isotope Dilution

March 11, 2018

Author(s)

Erdem Coskun, Vladimir Vartanian, Irina G. Minko, Onur Erdem, Pawel Jaruga, Patricia Egner, John D. Groopman

Dietary exposures to aflatoxin contaminated food is one of the major contributions to human hepatocellular carcinomas (HCCs) which accounts for over 700.000

Quantification Of Genomic DNA Damage In Lung and Nasal Epithelium and Response To Allergen Challenge

February 1, 2018

Author(s)

M Miral Dizdar, Koa Hosoki, Pawel Jaruga, Toshiko Itazawa, Erdem Coskun, Sanjiv Sur

Repair of oxidatively-induced DNA base lesions can stimulate innate and allergic airway inflammation. Specific allergenic extracts like ragweed pollen extract

Small molecule inhibitors of DNA glycosylases as potential drugs in cancer therapy

August 31, 2017

Author(s)

M Miral Dizdar, Aaron C. Jacobs, Nathan Donley, Marcus J. Calkins, Ajit Jadhav, Dorjbal Dorjsuren, David Maloney, Anton Simeonov, Pawel Jaruga, Erdem Coskun, Amanda K. McCullough, R. S. Lloyd

Statement of the Problem: Most chemotherapeutic agents kill cancer cells by damaging DNA. Cancer cells overexpress DNA repair proteins and thus increase DNA

Exposure to Engineered Nanomaterials: Impact on DNA Repair Pathways

July 13, 2017

Author(s)

Neenu Singh, Bryant C. Nelson, Leona D. Scanlan, Erdem Coskun, Pawel Jaruga, Shareen Doak

Some engineered nanomaterials (ENMs) may have the potential to cause damage to the genetic material in living systems. The mechanistic machinery functioning at

Enhancing the Efficacy of Cancer Therapy: Use of Small Molecule Inhibitors of DNA Glycosylases as Potential Drugs

March 12, 2017

Author(s)

Erdem Coskun, Aaron C. Jacobs, Nathan Donley, Marcus J. Calkins, Dorjbal Dorjsuren, David Maloney, Anton Simeonov, Pawel Jaruga, Amanda K. McCullough, M Miral Dizdar, R. S. Lloyd

Chemotherapy aims to destroy cancer cells by damaging their DNA. However, the overexpression of DNA repair proteins in cancer cells causes the removal of DNA

Repair of Oxidatively Induced DNA Damage by DNA Glycosylases

February 16, 2017

Author(s)

M Miral Dizdar, Erdem Coskun, Pawel Jaruga

Endogenous and exogenous reactive species cause oxidatively induced DNA damage in living organisms by a variety of mechanisms. As a result, a plethora of

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