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Search Publications by: Elijah Petersen (Fed)

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Displaying 1 - 25 of 100

Quantitative Evaluation of Released Nanomaterials from Carbon Nanotube Epoxy Nanocomposites during Environmental Exposure and Mechanical Treatment

September 29, 2023
Author(s)
Yue Zhao, David Goodwin, Lipiin Sung, Girish Ramakrishnan, Qiyuan Wu, Jiajie Cen, Elijah Petersen, Alexander Orlov
Carbon nanotubes (CNTs) are promising nanomaterials exhibiting high thermal and electrical conductivities, significant stiffness, high tensile strength, and light weight. As a result, CNTs have been utilized as additives to enhance properties of various

Federal perspective on critical research issues in nanoEHS

August 31, 2023
Author(s)
Janet Carter, Sri Nadadur, Rhema Bjorkland, William Boyes, Chuck Geraci, Vincent A. Hackley, John Howard, Alan Kennedy, Igor Linkov, Joanna Matheson, Holly Mortensen, Custudio Muinga, Elijah Petersen, Nora Savage, Stacey Standridge, Trey Thomas, Benjamin Trump
This article discusses critical issues and opportunities going forward in nanotechnology environmental, health, and safety (nanoEHS) research from the perspective of Federal Government agency participants in the U.S. National Nanotechnology Initiative (NNI

Orthogonal and complementary measurements of properties of drug products containing nanomaterials

January 6, 2023
Author(s)
Bryant C. Nelson, Elijah Petersen, Carl Simon Jr., Sven-Even Borgos, Luigi Calzolai, Jeremie Parot, Matthias Roesslein, Fanny Caputo, Xiaoming Xu
Quality control of pharmaceutical and biopharmaceutical products, and verification of their safety and efficacy, depends on reliable measurements of critical quality attributes (CQAs). The task becomes particularly challenging for drug products and

Potential artifacts and control experiments in toxicity tests of nanoplastic and microplastic particles

October 14, 2022
Author(s)
Elijah Petersen, Ana Barrios, Theodore Henry, Monique Johnson, Albert Koelmans, Antonio Montoro Bustos, Joanna Matheson, Matthias Roesslein, Jian Zhao, Baoshan Xing
To fully understand the potential ecological and human health risks from nanoplastics and microplastics (NMPs) in the environment, it is critical to make accurate measurements. Similar to past research on the toxicology of engineered nanomaterials, a broad

Technical Framework for High Quality New Approach Methodologies (NAMs)

July 15, 2022
Author(s)
Elijah Petersen, John T. Elliott, John Gordon, Nicole Kleinstreuer, Emily Reinke, Matthias Roesslein, Blaza Toman
New approach methodologies (NAMs) are in vitro, in chemico, and computational approaches that can potentially be used to reduce animal testing. For NAMs that require laboratory experiments, it is critical that they provide consistent and reliable results

Current Ecotoxicity Testing Needs Among Selected U.S. Federal Agencies

June 2, 2022
Author(s)
Patricia Ceger, David Allen, Elyssa Arnold, Jennifer Brennan, Lyle Burgoon, Raanan Bloom, Carol Clarke, Natalia Garcia-Reyero, Kellie Fay, Jon Hamm, Paula Henry, Wesley Hunter, Donna Judkins, Nicole Kleinstreuer, Carlie Lalone, James Laurenson, Jessica Leet, Scott Lynn, Teresa Norberg-King, Edward Odenkirchen, Elijah Petersen, Barnett Rattner, Catherine Sprankle, Thomas Steeger, Jim Warren, Sarah Winfield
U.S. regulatory and research agencies utilize ecotoxicity test data to assess the hazards associated with substances that are released into the environment, including consumer products, industrial chemicals, metals and metalloids, nanomaterials, and

IVIVE: Facilitating the use of in vitro toxicity data in risk assessment and decision making

May 1, 2022
Author(s)
Xiaoqing Chang, Yu-Mei Tan, David Allen, Shannon Bell, Paul Brown, Lauren Browning, Patricia Ceger, Jeffery Gearhart, Pertti Hakkinen, Shruti Kabadi, Nicole Kleinstreuer, Annie Lumen, Joanna Matheson, Alicia Paini, Heather Pangburn, Elijah Petersen, Emily Reinke, Alexandre Ribeiro, Nisha Sipes, Lisa Sweeney, John Wambaugh, Ronald Wange, Barbara Wetmore, Moiz Mumtaz
During the past few decades, the science of toxicology has been undergoing transformation from an observational to a predictive science. New approach methodologies (NAMs) including in vitro, in silico models, read across, and in vitro to in vivo

Current Nanomaterials Toxicity Testing Needs and Use of New Approach Methodologies Among Selected U.S. Federal Agencies

April 11, 2022
Author(s)
Elijah Petersen, Patricia Ceger, Jayme Coyle, David Allen, Raymond Derk, Natalia Garcia-Reyero, John Gordon, Nicole Kleinstreuer, Joanna Matheson, Danielle McShan, Bryant C. Nelson, Anil Patri, Liying Rojanasakul, Abhilash Sasidharan, Louis Scarano, Xiaoqing Chan
Engineered nanomaterials (ENMs) come in a wide array of shapes, sizes, surface coatings, and compositions, and often possess novel or enhanced properties compared to larger sized particles of the same elemental composition. To ensure the safe

Characteristics to Consider when Selecting a Positive Control Material for an In Vitro Assay

September 29, 2021
Author(s)
Elijah Petersen, Andrew Nguyen, Jeffrey Brown, John T. Elliott, Amy Clippinger, John Gordon, Nicole Kleinstreuer, Matthias Roesslein
The use of in vitro assays to inform decision-making requires robust and reproducible results across studies, laboratories, and time. Experiments using positive control materials are an integral component of an assay procedure to demonstrate the extent to

Parametric optimization of an air-liquid interface system for flow through inhalation exposure to nanoparticles: assessing dosimetry and intracellular uptake of CeO2 nanoparticles

September 29, 2021
Author(s)
Lars Leibrock, Harald Jungnickel, Jutta Tentschert, Aaron Katz, Blaza Toman, Elijah Petersen, Frank Bierkandt, Ajay V. Singh, Peter Laux, Andreas Luch
Air-liquid interface (ALI) systems have been widely used in recent years to investigate the inhalation toxicity of many gaseous compounds, chemicals, and nanomaterials and represent an emerging and promising in vitro method to supplement or ultimately

Resources for developing reliable and reproducible in vitro test methods

September 29, 2021
Author(s)
Elijah Petersen, Vytas Reipa, Menghang Xia, Monita Sharma
A broad range of in vitro test methods have been developed given their numerous potential advantages over in vivo tests. We describe here key resources and tools to increase the reliability and reproducibility of in vitro test methods.

Use of cause-and-effect analysis to optimize the reliability of in vitro inhalation toxicity measurements using an air-liquid interface

September 29, 2021
Author(s)
Elijah Petersen, Monita Sharma, Amy Clippinger, John Gordon, Aaron Katz, Peter Laux, Lars Leibrock, Andreas Luch, Joanna Matheson, Andreas Stucki, Jutta Tentschert, Frank Bierkandt
In vitro inhalation toxicology methods are increasingly being used for research and regulatory purposes. While the opportunity for increased human relevance of in vitro inhalation methods compared to in vivo tests has been established and discussed, how to

Combining secondary ion mass spectrometry image depth profiling and single particle inductively coupled plasma mass spectrometry to investigate the uptake and biodistribution of gold nanoparticles in Caenorhabditis elegans

May 20, 2021
Author(s)
Monique Johnson, Joe Bennett, Antonio Montoro Bustos, Shannon Hanna, Andrei Kolmakov, Nicholas Sharp, Elijah Petersen, Christopher Sims, Bryant C. Nelson, Patricia Lapasset
Analytical techniques capable of determining the spatial distribution and quantity (mass and/or particle number) of engineered nanomaterials in organisms are essential for characterizing nano-bio interactions and for nanomaterial risk assessments. Here, we

Comparative study of multiwall carbon nanotube nanocomposites by Raman, SEM, and XPS measurement techniques

March 3, 2021
Author(s)
Yanmei Piao, Vipin Tondare, Chelsea S. Davis, Justin Gorham, Elijah Petersen, Jeffrey W. Gilman, Keana Scott, Andras Vladar, Angela R. Hight Walker
Substantial ongoing research efforts are investigating the production of novel composite material enhanced by the incorporation of nanomaterial fillers such as multiwall carbon nanotubes (MWCNTs). While the addition of MWCNTs have been shown to improve the

Harmonizing Across Environmental Nanomaterial Testing Media for Increased Comparability of Nanomaterial Datasets

November 8, 2019
Author(s)
Nicholas Geitner, Christine O. Hendren, Geert Cornelis, Ralf Kaegi, Jamie Lead, Gregory Lowry, Iseult Lynch, Bernd Nowack, Elijah Petersen, Emily Bernhardt, Scott Brown, Warren Chan, Camille de Garidel-Thoron, Jaydee Hanson, Stacey Harper, Kim Jones, Frank von der Kammer, Alan Kennedy, Justin Kidd, Cole Matson, Christopher Metcalf, Joel Pedersen, Willie Peijnenburg, Joris Quik, Sonia Rodriguez, Jerome Rose, Phil Sayre, Marie Simonin, Claus Svendsen, Robert Tanguay, Nathalie Tukenji, Tom van Teunenbroek, Gregory Thies, Yuan Tian, Jacelyn Rice, Jie Liu, Jason Unrine, Marina Vance, Jason White, Mark Wiesner
The chemical composition and properties of environmental media play defining roles in determining nanomaterial (NM) transport, fate, biouptake, and even organism response. To compare and interpret experimental data, it is essential that sufficient context

Determining what really counts: Modeling and measuring nanoparticle number concentrations

August 1, 2019
Author(s)
Elijah J. Petersen, Antonio R. Montoro Bustos, Blaza Toman, Monique E. Johnson, Mark Ellefson, George C. Caceres, Anna Lena Neuer, Qilin Chan, Jonathan Kemling, Brian Mader, Karen E. Murphy, Matthias Roesslein
Elijah J. Petersen, Antonio Montoro Bustos, Blaza Toman, Monique Johnson, Mark Ellefson, George C. Caceres, Anna Lena Neuer, Qilin Chan, Jonathan Kemling, Brian Mader, Karen Murphy, Matthias Roesslein

Towards Sustainable Environmental Quality: Priority Research Questions for North America

July 30, 2019
Author(s)
Anne Fairbrother, Derek Muir, Keith Solomon, Gerald Ankley, Murray Rudd, Alistair Boxall, William Adams, Jennifer Apell, Bonnie Blalock, Sarah Bowman, Linda Campbell, George Cobb, Kristin Connors, David Dreier, Marlene Evans, Carol Henry, Robert Hoke, Magali Houde, Stephen Klaine, Rebecca Klaper, Sigrun Kullik, Roman Lanno, Charles Meyer, Elias Oziolor, Mary Ann Ottinger, Elijah Petersen, Helen Poynton, Pamela Rice, Gabriela Rodriguez-Fuentes, Alan Samel, Joseph Shaw, Jeffrey Steevens, Tim Verslycke, Scott Weir, Peter Wilson, Bryan Brooks
Anticipating, identifying and prioritizing strategic needs represent essential activities by research organizations. When these pursuits engage globally important environment and health goals, including the United Nations Sustainable Development Goals

Strategies for robust and accurate measurement of nanomaterial bioaccumulation

April 17, 2019
Author(s)
Elijah J. Petersen, Monika Mortimer, Robert Burgess, Richard Handy, Shannon Hanna, Kay Ho, Monique E. Johnson, Susana Louriero, Selck Henriette, Janeck Scott-Fordsmand, David Spurgeon, Jason Unrine, Nico van den Brink, Ying Wang, Jason White, Patricia Holden
One of the key components for environmental risk assessment of engineered nanomaterials (ENMs) is data on bioaccumulation potential. Accurately measuring bioaccumulation can be critical for regulatory decision making regarding material hazard and risk, and