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Search Publications by: Michihiro Nagao (Assoc)

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Displaying 26 - 33 of 33

Observation of Small Cluster Formation in Concentrated Monoclonal Antibody Solutions and Its Implications to Solution Viscosity

April 15, 2014
Author(s)
Eric J. Yearley, Paul D. Godfrin, Tatiana NMN Perevozchikova, Hailiang Zhang, Peter Falus, Lionel Porcar, Michihiro Nagao, Joseph E. Curtis, Pradad Gawande, Rosalynn Taing, Isidro E. Zarraga, Norman J. Wagner, Yun Liu
Monoclonal antibodies (mAbs) are a major class of biopharmaceuticals. Some concentrated mAb solutions are hypothesized to exhibit the formation of a solution phase consisting of reversibly self-associated aggregates (or reversible clusters), which is

Quasi-elastic Neutron Scattering Studies on Dynamics of Water Confined in Nanoporous Copper Rubeanate Hydrates

October 14, 2011
Author(s)
Takeshi Yamada, Ryo Yonaimine, Teppei Yamada, Hiroshi Kitagawa, Madhu Sudan Tyagi, Michihiro Nagao, Osamu Yamamuro
We have investigated the mechanism of the first order transition and proton conductivity in copper rubeanate hydrates from microscopic and dynamical points of view. Three different types of neutron spectrometer, time of flight, back scattering and neutron

Hierarchical Structure and Dynamics of an Ionic Liquid 1-Octyl-3-methylimidazolium Chloride

August 3, 2011
Author(s)
Osamu Yamamuro, Takeshi Yamada, Maiko Kofu, Masamichi Nakakoshi, Michihiro Nagao
We have performed the heat capacity, neutron diffraction, and neutron quasielas- tic scattering measurements of an ionic liquid 1-octyl-3-methylimidazolium chloride (C8mimCl). The heat capacity data revealed that C8mimCl exhibits a glass tran- sition with

Structure and Dynamics in Multicomponent Polyelectrolyte Solutions

March 11, 2008
Author(s)
Sanghun Lee, Vijay Tirumala, Michihiro Nagao, Taiki Tominaga, Eric K. Lin, Jian P. Gong, Wen-Li Wu
Double-network hydrogels (DN-gels) prepared from the combination of a moderately crosslinked anionic polyelectrolyte (poly(2-acrylamido-2-methyl-1-propanesulfonic acid, PAMPS) and an uncrosslinked linear polymer (polyacrylamide, PAAm) solution show strong