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Search Publications by: Anthony J. Kearsley (Fed)

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Displaying 26 - 50 of 72

Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics

January 1, 2019
Author(s)
Robert G. Brinson, John P. Marino, Frank Delaglio, Luke W. Arbogast, Ryan M. Evans, Anthony J. Kearsley, Yves Aubin, Gregory Pierens, Xinying Jia, David Keizer, Jonas Stahle, Goran Widmalm, Chad Lawrence, Patrick Reardon, John Cort, Koichi Kato, Stuart Parnham, Andreas Blomgren, Torgny Rundlof, Kang Chen, David Keire, Thea Suter-Stahel, Gerhard Wider, Donna Baldisseri, Julie Wu, Mats Wikstrom, Medhi Mobli
Of the top ten drugs on the global market in 2016, seven of them are biologics with a combined market value of over US$60 billion. Moreover, around 2,800 biopharmaceuticals, many of them monoclonal antibodies (mAbs), are in some stage of clinical

Combining fragment ion and neutral loss matching during mass spectral library searching: A new general-purpose algorithm applicable to illicit drug identification

November 20, 2017
Author(s)
Arun S. Moorthy, William E. Wallace, Anthony J. Kearsley, Dmitrii V. Tchekhovskoi, Stephen E. Stein
A mass spectral library search algorithm that identifies compounds that differ from library compounds by a single ‘inert’ structural component is described. This algorithm, the Hybrid Similarity Search, generates a similarity score based on matching both

Scaling Methods for Dynamic Building System Simulation in an HVACSIM+ Environment

August 9, 2017
Author(s)
Zhelun Chen, Jin Wen, Anthony J. Kearsley, Amanda Pertzborn
A robust and efficient nonlinear algebraic and differential equations solver is increasingly essential as the scale of dynamic building system simulation grows larger and the models employed become more complex. There are many factors affecting the

Phase Equilibria of the High Tc Superconductors in the (Bi, Pb) -SR-Ca-Cu-O System

February 19, 2017
Author(s)
Winnie Wong-Ng, Lawrence P. Cook, W Greenwood, Anthony J. Kearsley
Applications of (Bi,Pb)-Sr-Ca-Cu-O phase equilibria include material synthesis, melt processing and single crystal growth. Both liquidus and subsolidus data are of central importance. For the determination of liquidus data, we have used a wicking technique

Efficient and Robust Optimization for building energy simulation

June 15, 2016
Author(s)
Shokouh Pourarian, Jin Wen, Anthony J. Kearsley, Amanda Pertzborn
Efficiently, robustly and accurately solving large sets of structured, non-linear algebraic and differential equations is one of the most computationally expensive steps in the dynamic simulation of building energy systems. Here, the efficiency, robustness

Stochastic Regression Modeling of Chemical Spectra

August 14, 2014
Author(s)
Anthony J. Kearsley, William E. Wallace, Yutheeka Gadhyan
A stochastic regression method has been developed that decomposes chemical spectra into separate contributions from signal and from noise. The numerical results of regressing in this way on sample spectra are presented. The results suggest that this

Constrained Hierarchical Control of a Diffusion Equation

December 31, 2013
Author(s)
Anthony J. Kearsley
In this paper, we consider the approximate pointwise control of a linear parabolic system with multiple targets. The location of the pointwise controls are constrained and we assume hierarchy among the objectives, Optimality conditions are derived for a

Successive Frequency Domain Minimization for Time Delay Estimation

November 12, 2013
Author(s)
Ismet Sahin, Marwan A. Simaan, Anthony J. Kearsley
Estimating time delays for signal alignment is important for many applications. This paper extends a successful frequency domain cost function minimization algorithm capable of estimating time delays to within a fraction of sampling periods. Since a narrow

Automated Data Processing and Quantification in Polymer Mass Spectrometry

December 1, 2011
Author(s)
Till Gruendling, Christopher Barner-Kowollik, William E. Wallace, Charles M. Guttman, Anthony J. Kearsley
An overview is given of some new techniques in quantitative composition and molecular mass distribution measurement of synthetic polymers by mass spectrometry. New concepts in data analysis, including peak picking and integration, are also described.

Numerical Optimization of Matrix-Assisted Laser Desorption/Ionization Time-of- Flight Mass Spectrometry: Application to Synthetic Polymer Molecular Mass Distribution Measurement

May 26, 2007
Author(s)
William E. Wallace, Charles M. Guttman, Kathleen M. Flynn, Anthony J. Kearsley
A novel approach is described for the selection of optimal instrument parameters that yield a mass spectrum which best replicates the molecular mass distribution of a synthetic polymer. The application of implicit filtering algorithms is shown to be a

Flow Control Through the Use of Topography

May 1, 2007
Author(s)
David Cotrell, Anthony J. Kearsley
In this work, optimal shaft shapes for flow in the annular space between a rotating shaft with axially-periodic radius and a fixed coaxial outer circular cylinder are investigated. Axisymmetric steady flows in this geometry are determined by solving the