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Displaying 951 - 975 of 1612

Stable isotope-labeling of DNA repair proteins, and their purification and characterization

July 1, 2011
Author(s)
M Miral Dizdar, Pawel Jaruga, Prasad T. Reddy, Bryant C. Nelson, Mark S. Lowenthal
Reduced DNA repair capacity is associated with increased risk for a variety of disease processes including carcinogenesis. Thus, DNA repair proteins have the potential to be used as important predictive, prognostic and therapeutic biomarkers in cancer and

Comparison of segmentation algorithms for fluorescence microscopy images of cells

June 14, 2011
Author(s)
Alden A. Dima, John T. Elliott, James J. Filliben, Michael W. Halter, Adele P. Peskin, Javier Bernal, Marcin Kociolek, Mary C. Brady, Hai C. Tang, Anne L. Plant
Segmentation results from nine different segmentation techniques applied to two different cell lines and five different sets of imaging conditions were compared. Significant variability in the results of segmentation was observed that was due solely to

Negative Regulation of STAT3-mediated Cellular Respiration by SirT1

June 7, 2011
Author(s)
Lili Wang, Hua-Jun He, Michel Bernier, Rajib K. Paul, Alejandro Martin-Montalvo, Morten Scheibye-Knudsen, Shaoming Song, Sean M. Armour, Vilhelm A. Bohr, Yaping Zong, David A. Sinclair, Rafael de Cabo
In mammals, the transcriptional activity of signal transducer and activator of transcription 3 (STAT3) is regulated by the deacetylase SirT1. However, whether the newly described non-genomic actions of STAT3 toward mitochondrial oxidative phosphorylation

Physicochemical characterization and in vitro hemolysis evaluation of silver nanoparticles

June 7, 2011
Author(s)
Vytautas Reipa, Jonghoon Choi, Nam S. Wang, Victoria M. Hitchins, Peter L. Goering, Robert Malinauskas
In anticipation of the increased use of various forms of silver as an antimicrobial agent in medical devices, the objective of this study was to evaluate the in vitro hemolytic potential of silver nanoparticles in dilute human blood, and to relate particle

Tumor volume measurement errors RECIST studied with realistic tumor models

May 16, 2011
Author(s)
Benjamin R. Galloway, Adele Peskin, Zachary H. Levine
RECIST (Response Evaluation Criteria in Solid Tumors) is a linear measure intended to predict tumor volume in medical computed tomography (CT). In this work, using purely geometrical considerations, we estimate how well RECIST can predict the volume of

Reproducibility and Robustness of a Real-Time Microfluidic Cell Toxicity Assay

May 15, 2011
Author(s)
Gregory A. Cooksey, John T. Elliott, Anne L. Plant
Numerous opportunities exist to apply microfluidic technology to high-throughput and high-content cell-based assays. However, maximizing the value of these assays for drug discovery, screening or toxicity evaluation, for example, will require validation of

Tumor Volume Measurement Errors of RECIST Studied With Ellipsoids

May 5, 2011
Author(s)
Zachary H. Levine, Benjamin R. Galloway, Adele P. Peskin, C. P. Heussel, Joseph J. Chen
RECIST (Response Evaluation Criteria in Solid Tumors) is a linear measure intended to predict tumor volume in medical computed tomography (CT). In this work, using purely geometrical considerations, we establish limits for how well RECIST can predict the

NIST Reference Material Scaffolds Characterized for Cell Response

April 24, 2011
Author(s)
Carl G. Simon Jr., Jeff M. Coles
Reference scaffolds characterized for cell response are being developed for use as a standard for biological characterization of new scaffolds. The need for reference scaffolds to serve as a calibration standard between labs has been identified as critical
Displaying 951 - 975 of 1612
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