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Displaying 1 - 25 of 66

National Institute on Drug Abuse Clinical Trials Network Meeting Report: Managing Patients Exposed to Xylazine-Adulterated Opioids in Emergency, Hospital and Addiction Care Settings

March 16, 2024
Author(s)
Jeanmarie Perrone, Rachel Haroz, Joseph D'Orazio, Giacomo Gianotti, Jennifer Love, Matthew Salzman, Margaret Lowenstein, Ashish Thakar, Stephanie Klipp, Lisa Rae, Megan Reed, Edward Sisco, Rachel Wightman, Lewis Nelson
Used as a veterinary sedative and not approved for human use, xylazine has been increasingly linked with opioid overdose deaths in the United States. A growing number of people have been exposed to xylazine in the illicit opioid supply (especially fentanyl

Inferring the nominal molecular mass of an analyte from its electron ionization mass spectrum

August 23, 2023
Author(s)
Arun Moorthy, Anthony J. Kearsley, William Mallard, William E. Wallace, Stephen E. Stein
The performance of three algorithms for predicting nominal molecular mass from an analyte's electron ionization mass spectrum is presented. The Peak Interpretation Method (PIM) attempts to quantify the likelihood that a molecular ion peak is contained in

On the challenge of unambiguous identification of fentanyl analogs: exploring measurement diversity using standard reference mass spectral libraries

July 11, 2023
Author(s)
Arun Moorthy, Edward Erisman, Anthony J. Kearsley, Yuxue Liang, Edward Sisco, William E. Wallace
Fentanyl analogs are a class of designer drugs that are particularly challenging to unambiguously identify due to the mass spectral and retention time similarities of unique compounds. In this paper, we use agglomerative hierarchical clustering to explore

Rapid Analysis of Drugs: A Tool to Detect Drug Overdose Spikes, Build Trust Among People Using Drugs and Reduce Overdoses - Maryland, November 2021 - August 2022

April 28, 2023
Author(s)
Erin Russell, Edward Sisco, Allison Thomson, Jasmine Lopes, Dana Heilman, Margaret Rybak, Malik Burnett, Meghan Appley, Matthew Gladden
Maryland overdose deaths increased 16%, to a record high of 2,912 deaths during the 12-month period from July 2020 to June 2021. Illicitly manufactured fentanyl and/or fentanyl analogs* contributed to 84% of these overdose deaths.† Timely public health

Development & Validation of A Rapid GC-MS Method for Seized Drug Screening

February 15, 2023
Author(s)
Madeline Bloom, Edward Sisco, Ira Lurie
Controlled substances are one of the most frequently analyzed types of evidence in forensic laboratories. An increase in frequency of seizures in recent years has necessitated a need for rapid screening techniques to decrease case backlogs and expedite

Field-Deployable Devices

January 1, 2023
Author(s)
Thomas P. Forbes, Raychelle Burks
Reductions in instrument size, weight, and power continue to facilitate the development and application of field-deployable devices for investigative purposes. Portable analytical instrumentation supporting the rapid and reliable identification of two

Cannabis Laboratory Quality Assurance Program: Exercise 2 Moisture Final Report

November 29, 2022
Author(s)
Chuck Barber, Colleen E. Bryan Sallee, Carolyn Burdette, Shaun Kotoski, Melissa M. Phillips, Walter Brent Wilson, Laura Wood
In 2020, NIST launched Cannabis Laboratory Quality Assurance Program (CannaQAP) to improve the comparability of the analytical measurements of cannabis and cannabis-derived products in forensic and cannabis (hemp and marijuana) testing laboratories

A Template for the Validation of DART-MS for Qualitative Seized Drugs Analysis

March 10, 2022
Author(s)
Edward Sisco, Amber Burns, Elizabeth Schneider, Laurel Bobka, Ikenna Ikpeama
Direct analysis in real time mass spectrometry (DART-MS) is an increasingly employed tool for a wide range of forensic applications including seized drug analysis. A significant body of research surrounds DART-MS for the analysis of seized drugs and how it
Displaying 1 - 25 of 66