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Physics

Biological Physics

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Displaying 251 - 275 of 378

An Average Enumeration Method of Hyperspectral Imaging Data for Quantitative Evaluation of Medical Device Surface Contamination

September 15, 2014
Author(s)
Hanh Le, Moon Kim, Jeeseong C. Hwang, Yi Yang, Pawneena U-Thainual, Jin Kang, Do-Hyun Kim
We propose a quantification method called Mapped Average Principal component analysis Score (MAPS) to enumerate the contamination coverage on common medical device surfaces. The method was adapted from conventional Principal Component Analysis (PCA) on non

A Candidate Reference Analytical Method for Quantification of Low Concentrations of Plasmid DNA by Exhaustive Counting of Single DNA Molecules in a Flow Stream

August 4, 2014
Author(s)
Hee-Bong Yoo, Dong-Geun Oh, Jae Yong Song, Mamoru Kawaharasaki, Jeeseong C. Hwang, In Chul Yang, Sang-Ryoul Park
This work demonstrates accurate measurement of the concentration of low-level plasmid DNA by counting individual DNA molecules using a high-sensitivity flow cytometric setup. Plasmid DNA is a widely used form of DNA, and its quantity often needs to be

High-Speed Coherent Raman Fingerprint Imaging of Biological Tissues

July 20, 2014
Author(s)
Charles H. Camp, Young J. Lee, John M. Heddleston, Christopher M. Hartshorn, Angela R. Hight Walker, Jeremy N. Rich, Justin D. Lathia, Marcus T. Cicerone
We have developed a coherent Raman imaging platform using broadband coherent anti-Stokes Raman scattering (BCARS) that provides an unprecedented combination of speed, sensitivity, and spectral breadth. The system utilizes a unique configuration of laser

Dose calibrator manufacturer-dependent bias in assays of 123I

March 26, 2014
Author(s)
Denis E. Bergeron, Jeffrey T. Cessna, Daniel B. Golas, Rheannan K. Young, Brian E. Zimmerman
Calibration factors for commercial ionization chambers (i.e. dose calibrators) were determined for a solution of 123I; the activity was based on the 1976 NBS standard. A link between the NIST standard and the International Reference System (SIR) was

Quantifying short-lived events in multistate ionic current measurements

January 7, 2014
Author(s)
Arvind K. Balijepalli, Jessica H. Benjamini, Andrew T. Cornio, Joseph W. Robertson, Kin P. Cheung, John J. Kasianowicz, Canute I. Vaz
We developed a generalized technique to characterize polymer!nanopore interactions via single channel ionic current measurements. Physical interactions between analytes, such as DNA, proteins, or synthetic polymers, and a nanopore cause multiple discrete

Measurement Traceability in Medical Physics

January 1, 2014
Author(s)
Lisa R. Karam
Medical physics, the joining of physics with healthcare, requires a level of quality assurance beyond many applications of the physical sciences. Always the health, and often the life, of the patient depends on the precise and accurate implementation of

Absolute calibration of optical power and fluence rate for PDT: Report of AAPM TG140

July 23, 2013
Author(s)
Marla L. Dowell, Timothy Zhu, Christopher Bonnerup, Valdir Colussi, Jarod Finlay, Lothar Lilge, Thomas Slowery, claudio sibata
This report is primarily concerned with methods for optical calibration of laser power and light fluence rate for continuous wave (CW) light sources, predominantly used in photodynamic therapy (PDT). Dosimetry of light is very important for PDT, however

Multicomponent Chemical Imaging of Pharmaceutical Solid Dosage Forms with Broadband CARS Microscopy

July 15, 2013
Author(s)
Christopher M. Hartshorn, Marcus T. Cicerone, Young J. Lee, Charles H. Camp, John M. Heddleston, Patrick Marsac, Tim Rhodes, Zhen Liu, Nicole Canfield
We compare broadband coherent anti-Stokes Raman scattering (BCARS) microscopy with spontaneous Raman microscopy for quantitative and qualitative assessment of multicomponent pharmaceuticals. Indomethacin was used as a model active pharmaceutical ingredient
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