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Styliani (Stella) Alimperti

Project Leader at American Dental Association Foundation/ National Institute of Standard and Technology

     RESEARCH INTEREST

  • Organ-on-chip
  • 3D Printing Tissue Engineering 
  • Vascularization 
  • Personalized medicine

Research in my laboratory is focused on developing methods and technology aimed at reducing the burden of patient suffering from vascular diseases. My lab research interest is to develop new tissue engineering and regenerative therapies with emphasis on periodontal diseases. Periodontal diseases are considered the most expensive to treat, since it leads to tooth loss and the only solution is a tooth graft. Although different treatments have been developed against gum diseases, significant challenges remain, such as the high cost of tooth grafts and aging. In addition, patients who receive a tooth grafts are subject to lifelong side-effects such as increased rates of gum infections, diabetes and oral malignancies. Thus, it is necessary to engineer methods gum therapeutics, which can be applied to personalized medical treatment based on individual characteristics of each patient.

Microvascular complication is a primary cause of periodontal diseases such as gingivitis, periodontitis and gum cancer, thus a deeper understanding of the complex bidirectional and interdependent interactions between microvasculature and gum in pathophysiological conditions is needed. Thus, the research in my lab is focused on the development of new tools to identify new biological targets involved in microvascular diseases impacting oral medicine and in general, Cardiovascular medicine.

The integration of medicine and technology within a single framework for potential translational and therapeutic purposes of microvascular diseases. Such a vision requires a multidisciplinary research program which encompasses:

  1. Organ-on-a-chip technology to build multicellular level functional units of an organ through microengineering approaches. The engineered organ-on-a chip platforms are applied for drug testing and new pre-clinical target identification avoiding animal studies and impacting personalized medicine.
  2. Vascular biology to identify key biomechanical factors controlling blood vessel functionality.
  3. 3D printing technology to build functional vascularized organs-like models for in vitro and in vivo studies.

 

Note: We are seeking for scientists with demonstrated productivity and ability to work in a diverse and high energy environment.  We welcome inquiries about openings for postdoctoral fellows, interns and technicians which should include a cover letter, CV and published papers.  Please contact to: Stella Alimperti (email: styliani.alimperti@nist.gov)

 

Awards

GRANTS:  2018-2020: American Dental Association Foundation Award

PROFESSIONAL AFFILIATIONS: 

  • Member in American Institute of Chemical Engineers (AIChE).
  • Member in Biomedical Engineer Society (BMES).
  • Member in International Society for Stem Cell Research (ISSCR).
  • Member in Hellenic Bioscientific Association of USA (HBA).
  • Member in American Heart Association (AHA)
Created October 11, 2019