Meagan Cauble joined the Biomaterials Group in 2021 under the direction of Sumona Sarkar. Meagan has expertise in atomic force microscopy (AFM) imaging of extracellular matrix in musculoskeletal tissues to assess altered tissue structure from disease and drug treatment. Other research projects prior to NIST include growth factor signaling in intervertebral disc cells and multiplex probe development for image-based profiling of tyrosine phosphorylation.
At NIST, Meagan is developing a cell counting method based on genome copy number. This method integrates cell cycle characterization, quantification of DNA recovery during extraction, and absolute quantification of genomic targets in droplet digital PCR to calculate a cell count.
MA Cauble, NS Mancini, J Kalinowski, G Lykotrafitis, and IL Moss. Atomic force microscopy imaging for nanoscale and microscale assessments of extracellular matrix in intervertebral disc and degeneration. JOR Spine 2020 3(3):e1125.
M Cauble, P Yang, U Baumann, JM Gebauer, BG Orr, LT Duong, MM Banaszak Holl. Microstructure Dependent Binding of Pigment Epithelium Derived Factor (PEDF) to Type I Collagen Fibrils. Journal of Structural Biology 2017 199 132-139.
MA Cauble, M Muckley, M Fang, JA Fessler, K Welch, E Rothman, BG Orr, LT Duong, and MM Banaszak Holl. Estrogen depletion and drug treatment alter the microstructure of type I collagen in bone. Bone Reports 2016 5 243-251.
MA Cauble, E Rothman, K Welch, M Fang, LT Duong, BL Pennypacker, BG Orr, and MM Banaszak Holl. Alteration of Type I collagen microstructure induced by estrogen depletion can be prevented with drug treatment. BoneKEy 2015 4 697.
Full publication list can be found here: https://www.ncbi.nlm.nih.gov/myncbi/meagan.cauble.2/bibliography/public/