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Margaret Kline

Margaret worked for the Frederick Cancer Research Facility from1979 – 1985 where she conducted research in the isolation, and purification of novel anti-tumor antibiotics from fermentation broths.  Also, scaled-up isolation procedures from lab-scale to pilot-plant recovery scale. In 1985 she joined NIST to coordinate dispatching, receiving, storing, and processing of fat soluble vitamins in serum for a National Cancer Institute interagency program.  Which lead to her producing SRMs 968, 968a, 968b and 968c.

She started working on the PCR amplification of DNA for human identification in 1986 which has led to her interests in producing SRM 2391, SRM 2391a, SRM 2391b and SRM 2391c, for PCR technologies, and SRM 2372 for human DNA quantitation. Additionally, she has interest in conducting Interlaboratory Studies, Sanger sequencing variant STR samples, and qualifying digital PCR as a primary method of certifying quantitative SRMs of human DNA and plasmid DNA of viruses of clinical interest


2014 Judson C. French Award for SRM 2372

2008 Department of Commerce Gold Medal Award.
For research and measurement services in the area of human identity testing to support the criminal justice, legal, and disaster recovery communities.
2000 W.J. Youden Award in Interlaboratory Testing, American Statistical Association,
1995 Department of Commerce Bronze Medal Award.
For the development of SRM 2391, PCR-based DNA Profiling Standard which provides quality assurance for forensics and other human identification efforts.
1995 SRMP Measurement Services Award. For outstanding research and development and certification of SRM 2391, PCR-based DNA Profiling Standard.
1991 SRMP Measurement Services Award. For contributions to the formulation of materials and the analysis of data leading to the certification of SRMs 968 and 968a, Fat Soluble Vitamins in Human Serum.


Metrological Tools for the Reference Materials and Reference Instruments of the NIST Material Measurement Laboratory

Carlos R. Beauchamp, Johanna Camara, Jennifer Carney, Steven J. Choquette, Kenneth D. Cole, Paul C. DeRose, David L. Duewer, Michael S. Epstein, Margaret C. Kline, Katrice A. Lippa, Enrico Lucon, Karen W. Phinney, Maria Polakoski, Antonio M. Possolo, Katherine E. Sharpless, John R. Sieber, Blaza Toman, Michael R. Winchester, Donald A. Windover
The National Institute of Standards and Technology (NIST), formerly the National Bureau of Standards, was established by the U.S. Congress in 1901 and charged

NIST Micronutrients Measurement Quality Assurance Program: 1984-1985 Comparability Studies Results for Round Robins I, II, III and V Fat Soluble Vitamins and Carotenoids in Human Serum

Jeanice M. Brown Thomas, David L. Duewer, Margaret C. Kline, William A. MacCrehan, Robert Paule, Reenie Parris, Willie May, Robert Schaffer
From 1984 to 2017, the National Institute of Standards and Technology (NIST) and its precursor the National Burearu of Standards (NBS) coordinated what became
Created May 31, 2018