- National Institute of Standards and Technology, Guest Researcher, 2006-present
- Johns Hopkins University, Biomedical Engineering postdoctoral Fellow, 2000-2004
- University of Pennsylvania, Bioengineering postdoctoral Fellow, 2004-2005
- PhD in Biomedical Engineering, University of Minnesota, 2000
- MTech in Chemical Engineering, IIT Bombay, 1993
- BTech in Chemical Engineering, Andhra University, 1991
Dr. Bhadriraju is a Biomedical Engineer and a guest researcher in the Nanoscale Metrology group in the Physical Measurements Laboratory at NIST. His current work involves developing new methods to fabricate microfluidic devices, developing improved cell culture models for cancer cell-based drug testing, and developing new approaches to measure single-cell signaling, and mechanics. He has previously been involved in developing assays for microscopy-based measurement of force-generating signals within single cells, and methods for quantitative time-lapse microscopy of gene expression in stem cells.
Dr. Bhadriraju did his graduate training at IIT Bombay, and the University of Minnesota. He then went to Johns Hopkins University and The University of Pennsylvania for post-doctoral research in mechanobiology and tissue engineering. His doctoral and postdoctoral work showed among other things: that cell mechanical stiffness changes during adhesion and spreading, that changes in cell shape and internal signaling drive cell force-generating reactions which in turn control stem cell behavior, and that cell force-generating signals control cell growth (multiplication).
The overall goal of Dr. Bhadriraju’s research is to understand how physical forces regulate the function of living cells. Much remains to be known about such events, which dictate how cancer cells multiply or behave during metastasis, or how stem cells turn into tissue cells. Increased knowledge - supported by accurate measurement methods - can improve human health through better cancer therapies, and efficient approaches to engineer stem cells for regenerating damaged tissues.
Papers done previously to working at NIST:
Extracellular matrix-dependent myosin dynamics during G1-S phase cell cycle progression in hepatocytes, 2004, Bhadriraju K, and Hansen LK., Exp Cell Res. 2004 Nov 1;300(2):259-71. PMID: 15474992
- Cells lying on a bed of microneedles: an approach to isolate mechanical force, Tan JL, Tien J, Pirone DM, Gray DS, Bhadriraju K, and Chen CS, Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1484-9, PMID: 12552122
Extracellular matrix- and cytoskeleton-dependent changes in cell shape and stiffness, Bhadriraju K, Hansen LK, Exp Cell Res. 2002 Aug 1;278(1):92-100.