The mechanism behind pulsed high intensity focused ultrasound (pHIFU) effects leading to increased drug delivery are currently poorly understood. In this work, the thermal dose and peak temperatures associated with a typical pHIFU treatment were measured in mouse muscle. A non-ultrasonic hyperthermia (HT) treatment was then applied, designed to mimic the thermal component of the pHIFU treatment. The delivery of 200nm fluorescent nanoparticles was measured as a surrogate marker for drug delivery by pHIFU and HT treatments. Only the pHIFU treatment showed a significant increase in particle delivery.
Conference Dates: October 28-31, 2007
Conference Location: New York, NY
Conference Title: 2007 IEEE Int'l. Ultrasonic Symposium
Pub Type: Conferences
drug delivery, high intensity focused ultrasound, hyperthermia, thermal mechanism