In work sponsored by the National Institute of Standards and Technology and the Next-Generation Fire Suppression Technology Program, our current research effort is directed toward the continued study of known promising as well as several new chemical families with potential as sources of Halon 1301 replacement compounds for aircraft applications. This effort continues the study of tropodegradable alkenes and ethers as well as efforts to identify screening methods for cardiac sensitization. NIST Technical Note 1443, "Alternative Fire Suppressant Chemicals: A Research Review with Recommendations", provided the basis for this project through a systematic evaluation and prioritization of a broad range of chemical families for further study . This survey resulted in several chemical families being classified as High Priority for future research efforts. Additional chemical families were identified as worthy of Further Study or Quick Look investigation. Identifying a compound whose cardiac sensitization properties approximate the LOAEL and NOAEL values of Halon 1301 is a fundamental progammatic goal; therefore, refinement in the methods employed in the estimation and ranking of a compound's cardiac sensitization properties continue to be of great interest. As preliminary screening methods, water-octanol partition coefficients and in vitro tissue methods offer hope of meeting near-term needs for screening compounds. These methods would not, however, be expected to supplant the formal dog exposure-based cardiac sensitization test; instead, these methods could be an aid in the preselection of compounds; serving to highlight and advance very promising candidates to consideration for the formal cardiac sensitization test. This NIST-funded project continues the study of tropodegradable candidates and also expands the search to the study of the promising chemical families identified in NIST Technical Note 1443.
Citation: Special Publication (NIST SP) - 984-4
NIST Pub Series: Special Publication (NIST SP)
Pub Type: NIST Pubs