Material properties and their interactions with biological components dictate the performance of devices and drug carriers. Reliable, robust measurements and standards are needed to maximize the success of clinical outcomes.
There is a high demand for NIST Calcium Hydroxyapatite Standard Reference Materials (SRM) continues to grow with our latest supply not lasting as long as expected. NIST is in the process of completing certification and the Report of Analysis for SRM 2910b: Calcium Hydroxyapatite, a new batch of SRM. As a part of the corresponding research portfolio, the team is developing additional SRMs with more biologically relevant properties to better mimic bone and teeth. Research efforts have included directed biomineralization processes to anticipate the needs in advanced materials. This work is partially supported by the National Institute of Dental and Craniofacial Research (NIDCR/NIH) through interagency agreements to develop robust, standardized measurements for industry and academia.
NIST was the first to show that ns material dynamics could track protein stability in solid storage formats. We demonstrated that the same ns dynamics measured with neutron scattering could be obtained from time-dependent fluorescence experiments. Those measurements were more generally accessible, but still not amenable to use in a biopharmaceutical process lab. We are now developing a tabletop steady-state fluorescence instrument that could easily be used in a biopharmaceutical lab, and that gives a signature of the relevant ns dynamics.