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How Well Do You Know Your Kidneys?

NIST SRM 2925 Recombinant Human Serum Albumin Solution (Primary Reference Calibrator for Urine Albumin) (Frozen)

SRM 2925

What: SRM 2925 is a frozen aqueous solution of recombinant human serum albumin (HSA).  The SRM consists of two vials, each containing approximately 0.50 mL of frozen solution.

Why: Urine albumin is a major clinical biomarker of acute renal failure and chronic kidney disease. HSA is measured in human urine for clinical diagnosis of renal dysfunction and the evaluation of treatment efficacy.

Who: Clinical researchers and in-vitro diagnostics manufacturers working towards the accuracy and comparability of routine clinical urine albumin measurements.

How: SRM 2925 is intended for use as a primary reference calibrator for the quantification of HSA in human urine by LC-MS/MS measurement methods.  This SRM can also be used to assess the accuracy of calibrators and control materials used for the quantification of HSA using LC-MS/MS measurement methods.  An international certified reference material for HSA should improve the equivalence of measurement results between different measurement methods and across geographic locations.

Released March 2, 2020, Updated February 27, 2020