Projects/Programs

Displaying 1 - 3 of 3

An engineered bacterial sensor is placed in a contaminated pond containing PFAS. RNA circuits in the bacterial chassis measure PFAS-specific RNA signatures. The bacterial sensor turns pink in response to the presence of PFAS.

Engineering Living Measurement Systems to Sense PFAS

Ongoing

Per- and polyfluoroalkyl substances, PFAS, are thermodynamically stable organic fluorinated chemicals that are resistant to traditional degradation pathways leading to concern for bioaccumulation. These compounds originate from several industrial manufacturing processes and are found in soil systems...

Modeling toehold mediated strand exchange circuits across environments and applications

Ongoing

A major goal of engineering biology is the ability to use first principles to rationally design genetic circuits that process molecular information. Toehold-mediated strand exchange (TMSE) circuits act as highly programmable molecular computers made of DNA and RNA, and they are gaining traction due...

RNA Computation and Metrology for Engineering Biology

Ongoing

RNA computation RNA computation, i.e., programmed interactions between RNA molecules that process information, is an increasingly useful synthetic biology tool with applications spanning in vitro biosensing, synthetic cells, and cellular control. We have developed cotranscriptionally encoded RNA...

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