Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Projects/Programs

Topic Area
Displaying 1 - 25 of 201

AAPS Interlaboratory Study: Protein Aggregation and Immunogenicity

Ongoing
To ensure the safety and efficacy of protein-based biotherapeutics, manufacturers strive to avoid unwanted immune responses caused by the biotherapeutic. Protein immunogenicity is a complex topic and depends on multiple factors related to the product, patient profile, and treatment. 1 , 2...

Accurate Mapping of Thermal Properties at the Nanoscale

Ongoing
Continuous advances in the performance and functionality of semiconductor devices have been driven by scale reduction, incorporation of new and nanomaterials, and by heterogeneous integration (HI). However, such scaling and integrated architecture has rendered existing thermal metrology inadequate...

Additive Manufacturing of Ceramics

Ongoing
Additive manufacturing (AM) is a rapidly growing suite of technologies that has been a national priority since 2012. Compared to metals and polymers AM, the commercial adaptation of ceramics AM is still in its infancy. Nevertheless, ceramics AM is actively explored for applications in aerospace...

Additive Manufacturing Fatigue and Fracture

Ongoing
RESEARCH HIGHLIGHTS FACILITIES and CAPABILITIES PUBLICATIONS - see individual staff webpages on right POST-DOCTORAL OPPORTUNITIES - jump to section below Metal additive manufacturing (AM) is not used in fatigue and fracture critical applications despite industrial need. The goal of this project is...

Additive Manufacturing of Metals

Ongoing
The Additive Manufacturing of Metals Project, which has participants from multiple groups and divisions, and has three primary objectives: Develop and utilize novel local and in situ measurement capabilities for establishing AM mechanisms responsible for processing and post-processing pathways in AM...

Advanced Data Exchange Standards for the Biomanufacturing Supply Chain

Ongoing
Objective The objective of this project is to develop measurement science that includes methods, workflow models, information meta-models, interoperability metrics, and prototype tools to help U.S. manufacturers reduce the time and cost associated with making supply chain data accessible for better...

Advanced Informatics and Artificial Intelligence for Additive Manufacturing

Ongoing
Objective To develop and deploy the metrics, models, and best practices for implementing and adopting advanced informatics (including product definition, digital twins, machine learning and advanced analytics) and artificial intelligence to enhance additive manufacturing design, process planning...

Advanced Machines, Monitoring, and Control for AM

Ongoing
Objective To develop, integrate, and implement real-time feedback and other cutting-edge process control techniques using advanced monitoring tools such as high-speed imaging and diffraction for single and multi-laser AM systems. Technical Idea The current methods for AM control predominantly rely...

Advanced Manufacturing Data Infrastructure and Analytics Program

Ongoing
Objective The Advanced Manufacturing Data Infrastructure and Analytics (AMDIA) Program will develop and deploy measurement science to advance a data infrastructure that will improve the productivity, resiliency, and sustainability of manufacturing operations and supply chains to enhance U.S...

Advanced Metrology to Enable Next Generation EUV Photoresists

Ongoing
EUV (extreme ultraviolet) lithography, the technology that “saved Moore’s Law,” is widely regarded as the future of cutting-edge nanofabrication. It was developed in the United States and U.S. companies in many parts of the EUV ecosystem have established dominance in the field that must be defended...

Advancing Power Electronics with Defect Metrology

Ongoing
Power electronics play a central role in all aspects of electrical energy storage, distribution, conversion, and consumption. Currently, power electronics heavily rely on Si-based insulated-gate bipolar transistors (IGBT), which have large footprints, are inefficient, and require extensive cooling...

Agility Performance of Robotic Systems

Ongoing
Objective Deliver robot agility performance metrics, test methods, information models, datasets, combined virtual/real testbeds, and planning approaches that will enable manufacturers to more easily and rapidly reconfigure, retask, and redeploy robotic systems. Technical Idea The project is...

Agri-Food Manufacturing System and Supply Chain Integration

Ongoing
Objective: Deploy new standards and reference data supporting agri-food manufacturing systems to enable industry to more efficiently and cost effectively produce food-based products of higher quality and with improved food safety. Technical Idea: Today, food producers face many challenges include...

Assay Development for Cell-Free Expression Systems

Ongoing
Current practices for characterizing cell-free expression systems are limited and unsuitable to advance these technologies beyond the state-of-the-art. To meet this measurement need, the Cellular Engineering Group is developing quantitative assays to benchmark cell extracts, reagents, and cell-free...

Augmented Intelligence for Manufacturing Systems (AIMS)

Ongoing
Objective To overcome existing measurement challenges via augmented intelligence, the fusion of integrated metrology, physics-based models, and artificial intelligence, to enable monitoring, diagnostics, and prognostics of manufacturing systems and their processes. Technical Idea One research...

EV Battery Passport

Completed
End-of-life issues associated with EV batteries (EVBs) are estimated to have a steep rise in the coming decades. Given the finite nature of material resources worldwide, developing a circular EV batteries (EVB) infrastructure is needed to keep high value battery materials in the economy, therefore...

Biofabrication of Tissue Engineered Constructs

Ongoing
OCT imaging was assessed using a model scaffold-cell system consisting of a polysaccharide-based hydrogel seeded with human Jurkat cells. Four test systems were used: hydrogel seeded with live cells, hydrogel seeded with heat-shocked or fixed dead cells and hydrogel without any cells. Time series...

Biomanufacturing Initiative

Ongoing
The objective of the NIST biomanufacturing program is to support US biopharmaceutical industry delivery of high quality and low cost protein drugs around the world. The mission is fulfilled through the development of standards, measurement science, and state of the art tools that support advances in...

Bioprocess Modeling for Expansion of Cell Culture

Ongoing
One of the most critical steps in bioprocessing is the controlled expansion of frozen cell cultures to generate sufficient cell quantities for manufacturing cell-based products or assay systems. This project focuses on building a scalable model for cell expansion processes that can support the...

Building System Economics

Ongoing
Objective To develop and deploy transparent, open source standards-based data and tools that quantify the life-cycle performance of building technologies and systems through parallel activities focused on developing, releasing, and expanding capabilities and adoption of: (1) the Economic Evaluation...

Cell Line Authentication

Ongoing
Cell Line Authentication – The scientific community has responded to the misidentification of human cell lines with validated methods to authenticate these cells; however, there are few assays available for nonhuman cell line identification. We have developed multiplex polymerase chain reaction (PCR...

Cell Viability for Advanced Therapies

Ongoing
In the Biosystems and Biomaterials Division at NIST, we have established several technical programs to support the development and implementation of cell viability assays in advanced therapies. These programs address key needs in cell viability assay development including selection and development...
Was this page helpful?