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Standards

Reference materials

Projects/Programs

Keyword

Organizational Unit

RM 8376 Microbial Pathogen DNA Standards for Detection and Identification

Ongoing

RM 8376 consists of 20 individual gDNA components from 19 bacterial strains and 1 human reference genome. Its purpose is to enable developers and regulators to evaluate the analytical performance of metagenomic next generation sequencing (mNGS) tools. The material is certified for chromosomal copy

Photograph of a labeled amber bottle containing SRM 2429.

Activated Carbon and FGD Gypsum Standard Reference Materials

Completed

The role of mercury in the environment is now receiving close scrutiny because ultimately it can bioaccumulate as alkyl mercury in seafood with subsequent risk to human health through trophic transfer. Many industrial sources of mercury have been effectively reduced in recent years, but atmospheric

Audit of EPA Protocol Gas Suppliers

Ongoing

Protocol gas standards are employed in measurements made for compliance purposes; one of the major uses is for measurements of regulated gaseous species from stationary source emitters, i.e., stack gases. Many of these stationary sources are regulated through the Cap and Trade program; therefore

Basic Metrology (Archive): Primary Radioactivity Standardization of Ni-63

Completed

Generally, 63Ni has great utility as a low-energy β - calibration standard because of the favorable combination of long half-life (T = 100 a) and β - endpoint energy. Primary standardizations of 63Ni have been actively pursued by national radionuclidic metrology laboratories for over 40 years. As a

Basic Metrology (Archive): Standardization of Am-243

Completed

The radionuclide 243Am decays by alpha emission and it is the most stable of the americium isotopes however, is not found in nature. It is formed in the nuclear fuel cycle by neutron capture on 242Pu followed by beta decay. It is used as a monitor for radioactive contamination and as a tracer on

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Basic Metrology: Design and Construction of a New Cs-137 Gamma-ray Calibration Facility

Completed

The new facility was built from the ground up, starting with an empty room, based on original design specifications developed by the Dosimetry Group at NIST. It is divided into two areas (control and irradiation) that are isolated from each other. The irradiation area contains a new 137Cs gamma-beam

Biomanufacturing Initiative

Ongoing

The objective of the NIST biomanufacturing program is to support US biopharmaceutical industry delivery of high quality and low cost protein drugs around the world. The mission is fulfilled through the development of standards, measurement science, and state of the art tools that support advances in

Biomaterials for Oral Health

Completed

NIST along with its partners has a long commitment to scientific excellence with demonstrated impact in improving the oral health of the public. NIST researchers are leaders in this field and create a community by engaging other researchers, industry, and regulatory agencies to address urgent needs

Bioprocessing Laboratory

Ongoing

Current Capabilities Computer controlled liquid nitrogen biostorage system Two culture areas including 4 monitored CO2 incubators 2 Six-foot BSLII biosafety cabinets Measurements- cell count and concentration, STR typing, flow cytometry, cell volume size distribution, conventional transmission and

Cancer Biomarker Measurements and Collaborations

Ongoing

Collaborations and Cooperative Research Agreements We welcome collaborations and can help with assay validation and development of reference materials. Below are some examples of our collaborations and ways we can develop test materials. Early Detection Research Network (EDRN): Interagency agreement

Carbon Capture, Use, and Storage

Ongoing

Carbon Capture, Use, and Storage (CCUS) requires a suite of technologies to capture carbon dioxide from industrial point sources, the atmosphere, and the ocean; convert carbon dioxide into products such as fuels, chemical feedstocks, and building materials; and sequester carbon dioxide deep

Image showing a variety of gas tanks with carbon dioxide

Carbon Dioxide Measurements and Reference Materials

Ongoing

CO 2 Reference Materials The Gas Sensing Metrology Group at NIST has a long history of providing reference materials to industry, monitoring communities, and academia. The program began in the 1970’s by developing an initial suite of CO2 primary standard mixtures (PSMs) to support the US Department

Wordcloud consisting of words CCQM metrology group task etc.

CCQM Activities in the Gas Analysis Working Group

Ongoing

The results from these Key comparisons will be used to benchmark the appropriate Calibration and Measurement Claims (CMCs) of the participating NMIs. CMCs are basically the declared capabilities that an NMI offers to customers, and they are included in a searchable database at the BIPM web site

CCQM Activities in the Organic Analysis Working Group

Ongoing

The results from these studies will be used to demonstrate the capabilities of participating NMIs for their similar measurement services, and eventually benchmark the appropriate  Calibration and Measurement Capabilities (CMCs) that summarizes this capability.  NIST CMCs that directly support SI

Certification of Three Soil SRMs for Inorganic Environmental Measurements

Completed

The three NIST soil SRMs, 2709, 2710 and 2711, have been used worldwide by hundreds of laboratories; combined sales typically exceed 800 units per year. Use of these SRMs provides our customers with tools that are essential for achieving quality assurance in the analysis of contaminant elements in

Photograph of a unit of RM 8027 Silicon Nanoparticles (Nominal Diameter 2 nm) showing a labeled box and ampoules.

Chemical Characterization of Nanoparticles

Ongoing

NIST has a broad research program spread throughout the major operating units aimed at building the supporting technical capabilities that U.S. industry needs in their quest to develop new nanotech products with desirable new capabilities and bring them safely to market. The Chemical Sciences

Photograph of titanium metal crystal with cubic symmetry.

Chemical Metrology for Metals, Ores, and Related Materials

Ongoing

In the arena of industrial commodities, the primary challenges are to provide measurement tools and reference materials that allow U.S. industry to establish comparability of measurement results to results obtained by customers, competitors, and regulators for the basic chemical properties of

Chemical Metrology for Polymers Manufacturing

Ongoing

This project is designed to strengthen the analytical capabilities of polymers manufacturers by introducing reference materials, critically evaluating standard test methods, and educating those industry representatives who participate in standards development organizations. Certified reference

Illustration of satellite sensing of sunlight reflected by buildings, roads, water and trees to assess radiative warming of the earth.

Climate Science

Ongoing

This program encompasses multifaceted efforts to advance the metrology of climate science. Projects include: development of ultra-high accuracy optical standards and technologies to determine greenhouse gases (GHGs) concentrations, atmospheric lifetimes, and aerosol radiative forcing development of

Clinical and Forensic Reference Materials

Ongoing

Below is a listing of the reference materials currently produced by the Applied Genetics group. Clinical Diagnostics SRM 2393 - CAG Repeat Length Mutation in Huntington`s Disease SRM 2365 - BK Virus DNA Quantitative Standard SRM 2366a - Cytomegalovirus DNA (Towne Δ147 BAC) for DNA SRM 2367 - JC

Clinical Measurements Quality Assurance Program

Ongoing

The National Institute of Standards and Technology (NIST) established the Clinical Measurements Quality Assurance Program (ClinQAP) to support the measurement needs of the clinical community. Participants measure concentrations of marker compounds, contaminants, metabolites in clinical samples (e.g

A Comparison of WD-EPMA Heterogeneity Testing Procedures

Ongoing

X-ray stage mapping (XSM) can be used to determine the extent of heterogeneity on the micron scale though it is more time consuming and not as accurate as the more rigorous NIST random-point (RP) testing procedure. The objective of this work is to demonstrate the advantage of the latter procedure

Consistency Analysis and Uncertainty in ‘omic Data

Ongoing

‘Omics is increasingly moving out of the laboratory and towards use in industrial and commercial applications. For instance, in biomanufacturing, there is a need for quality control when developing biotherapeutics, which will almost certainly require a machine-learning classifier to separate

Continuing Support of Cement Manufacturing

Ongoing

NIST SRMs for Portland cement and related materials are the de facto world standards for validation of analytical methods for testing of cement for compliance with manufacturing specifications and for qualification of laboratories throughout the supply chain, including cement plants, construction

Cover of the ASME International Steam Tables for Industrial Use, Third Edition

Contributions to International Standards on the Properties of Water

Ongoing

Water is probably the most widely used industrial fluid and it is important to have internationally accepted standards for its properties. This information is crucial to the analysis and design of thermal power cycles, as well as for climate studies including the hydrosphere. (Here is a summary of

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