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Chemistry

Projects/Programs

Keyword

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Computational Biology: Comparison of Cell Image Segmentation Algorithms

Ongoing

With the advent of automated data acquisition systems in conjunction with on-line imaging devices, the biological researcher is potentially confronted with

Computational Chemistry

Ongoing

Ab initio computational chemistry is considered to be one of the holy grails of computational science. The benefits to society range from lighter, stronger

Connecting Thermodynamic and Dynamic Properties of Bulk and Confined Fluids

Ongoing

It is well known that the physical properties of a fluid can change profoundly, and often non-trivially, when placed in a confined environment. Only for the

Consistency Analysis and Uncertainty in ‘omic Data

Ongoing

As ‘omics moves into industrial and commercial applications, there is a need for quality and process control to ensure safety and efficacy of products and

Continuing Support of Cement Manufacturing

Ongoing

Cement manufacturers and their customers rely on the NIST Portland cement SRMs for laboratory qualification under ASTM International C 114-07 Standard Test

Cover of the ASME International Steam Tables for Industrial Use, Third Edition

Contributions to International Standards on the Properties of Water

Ongoing

Researchers in the Applied Chemicals and Materials Division play a leading role in the development of international standards for the properties of water. This

Data and Computational Tools for Advanced Materials Design: Structural Materials Applications - Cobalt Based Superalloys

Ongoing

The development of a materials innovation infrastructure (MII) that will enable rapid and significant reductions in the development time for new materials with

Density Functional Tight Binding Methods

Density Functional Tight Binding (DFTB) methods have been shown to be capable of producing reliable molecular structures and energetics at a significantly

Development of Biomarker-based Systems for Cancer Detection and Therapy

Ongoing

Biomarkers play an increasingly important role in disease detection and treatment. As one of the Biomarker Reference Laboratories (BRLs) in the Early Detection

Development of Enhanced mRNA Amplification Using Microfluidics

Ongoing

In conjunction with NCI/NIH, NIST is developing methods to improve mRNA amplification from small biological samples. Typical sample processing requires

Development of Methods for Measurement of Vitamin D and its Metabolites in Foods, Fortified Foods, and Dietary Supplements

Ongoing

Vitamin D is a fat-soluble vitamin that is essential for bone health. Vitamin D deficiency is associated with muscle weakness and osteoporosis and can

Development of Proteomics-Based Methods for Protein Quantification

Ongoing

NIST is developing methods for the quantification of clinically-relevant protein biomarkers by mass spectrometry. Some methods are intended to establish

Development of Reference Methods and Reference Materials for the Determination of Cardiac Troponin I in Human Serum

Ongoing

Cardiac troponin I (cTnI) is considered the 'gold standard' for the diagnosis of myocardial infarction and the assessment of cardiac damage. Yet this clinical

Development of Reference Methods and Reference Materials for Proteins

Ongoing

A number of proteins show promise as potential markers of health or disease, and commercial assays are being developed for these proteins. For example

Development of Reference Methods and Reference Materials for the Determination of Hormones in Human Serum

Ongoing

Hormones are chemical messengers that regulate many life functions, and deviations from normal levels can indicate serious health problems. Measurement of

Photograph of SRM 2669 Arsenic Species in Frozen Human Urine, with vials and desiccant packs, and labeled mylar bag.

Development of SRM 2669 for Accurate Assessment of Arsenic Exposure

Ongoing

The National Institute of Standards and Technology (NIST), in collaboration with the Centers for Disease Control and Prevention (CDC), has developed Standard

Development of SRMs 2668 and 3668 for Accurate Assessment of Exposure to Toxic Elements and Anions

Completed

As part of a multi-year interagency agreement between the National Institute of Standards and Technology (NIST) and the Centers for Disease Control and

Development of SRMs for Serum Proteomics

Ongoing

Serum proteomics, the detection and measurement of as many proteins in a serum sample as possible, could be an important element of personalized medicine

Dietary Supplement Laboratory Quality Assurance Program (DSQAP)

Ongoing

The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health (NIH) Office of Dietary Supplements (ODS)

Differential absorption LIDAR for the detection and quantification of greenhouse gases

Ongoing

We are developing a method for accurately quantifying greenhouse gas emissions from natural and anthropogenic sources and sinks to meet the requirements for

Digital PCR

Ongoing

Digital PCR (dPCR) is a method used to quantify nucleic acids (DNA, RNA, cDNA). At NIST we are using microfluidic and emulsion-based dPCR platforms for

DNA Profiling Standard Reference Materials

Ongoing

NIST has produced several PCR-based DNA Profiling Standard Reference Materials (SRMs) for the forensic community. The primary uses of these materials are

Ecogenotoxicity Measurements of Nanoparticles

Ongoing

As a result of their novel properties, nanoparticles are expected to be produced and incorporated into consumer products at exponentially increasing quantities

Effect of Partial Charge Calculation Method on Adsorption Thermodynamics in Metal-organic Frameworks

Ongoing

In classical molecular simulations, electrostatic contributions to the potential energy are typically accounted for by assigning partial charges to some or all

Electrochemistry

Ongoing

In this project we develop and apply electrochemical and surface science principles to the study of advanced wet chemical deposition processes and emerging

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---Biosystems and Biomaterials Division
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----Complex Microbial Systems Group
----Cell Systems Science Group
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----Biochemical and Exposure Science Group
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----Optical Measurements Group
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---Quantum Measurement Division
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