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Bioscience

Projects/Programs

Keyword

Organizational Unit

Consistency Analysis and Uncertainty in ‘omic Data

Ongoing

As ‘omics moves into industrial and commercial applications, there is a need for quality and process control to ensure safety and efficacy of products and

Controlling Microfluidic Cell Cultures

Ongoing

NIST has taken advantage of recent technological advances to develop polymer microfluidic cell culture systems that provide a level of control over the cellular

DARPA Friend or Foe (FoF) -- Independent Verification and Validation (IV&V)

Ongoing

The development of new platforms for characterization of complex microbial samples are hampered by lack of reproducibility and comparability across different

Decontamination of Biological Threats in Water Supplies

The availability of safe pure drinking water in the United States is taken for granted. The presence of dangerous microorganisms, viruses and toxins in our

Development of Biomarker-based Systems for Cancer Detection and Therapy

Ongoing

Biomarkers play an increasingly important role in disease detection and treatment. As one of the Biomarker Reference Laboratories (BRLs) in the Early Detection

Development of a Collagen Fibril Reference Material for Reproducible Cell Response

Ongoing

An important determinant of cellular response to drugs and toxins is the chemical and physical nature of the extracellular matrix (ECM) to which cells are

Development of Enhanced mRNA Amplification Using Microfluidics

Ongoing

In conjunction with NCI/NIH, NIST is developing methods to improve mRNA amplification from small biological samples. Typical sample processing requires

Development of Methods for Measurement of Vitamin D and its Metabolites in Foods, Fortified Foods, and Dietary Supplements

Ongoing

Vitamin D is a fat-soluble vitamin that is essential for bone health. Vitamin D deficiency is associated with muscle weakness and osteoporosis and can

Development of the NIST Prototype Advanced Biometrology Laboratory

Ongoing

Blog detailing the renovation, retrofitting, and assembly of new type of metrology laboratory

Development of NIST Reference Materials for Untargeted Metabolomics, Lipidomics and Proteomics

Ongoing

The use of metabolite, lipid, and protein profiles for systems biology, biomedical research, and clinical applications has risen dramatically over recent years

Development of Proteomics-Based Methods for Protein Quantification

Ongoing

NIST is developing methods for the quantification of clinically-relevant protein biomarkers by mass spectrometry. Some methods are intended to establish

Development of Rapid Multiplex PCR Techniques

Ongoing

Forensic DNA typing is currently conducted in approximately eight to ten hours. The process includes DNA extraction, quantitation, multiplex PCR amplification

Computer-generated image of the structure for C-reactive protein

Development of a Reference Measurement Procedure for C-Reactive Protein in Human Serum

Completed

C-reactive protein (CRP) levels in serum or plasma have been used as an indicator of inflammation and infection. Recent evidence also suggests that CRP levels

Development of Reference Measurement Procedures and Reference Materials for Creatinine

Ongoing

Chronic kidney disease (CKD) is a growing problem in the U.S., and current estimates suggest that more than 20 million Americans are affected by this disease

Development of Reference Methods and Reference Materials for the Determination of Hormones in Human Serum

Ongoing

Hormones are chemical messengers that regulate many life functions, and deviations from normal levels can indicate serious health problems. Measurement of

Development of Reference Methods and Reference Materials for Clinical Diagnostic Markers

Ongoing

The accuracy of clinical diagnostic measurements is essential for reliable diagnosis and cost-effective treatment of disease. NIST's involvement in reference

Development of Reference Methods and Reference Materials for Proteins

Ongoing

A number of proteins show promise as potential markers of health or disease, and commercial assays are being developed for these proteins. For example

Development of Reference Methods and Reference Materials for the Determination of Cardiac Troponin I in Human Serum

Ongoing

Cardiac troponin I (cTnI) is considered the 'gold standard' for the diagnosis of myocardial infarction and the assessment of cardiac damage. Yet this clinical

Development of SRMs for Serum Proteomics

Ongoing

Serum proteomics, the detection and measurement of as many proteins in a serum sample as possible, could be an important element of personalized medicine

Digital PCR

Ongoing

Digital PCR (dPCR) is a method used to quantify nucleic acids (DNA, RNA, cDNA). At NIST we are using microfluidic and emulsion-based dPCR platforms for

DNA Biometrics

Ongoing

There is ongoing interest in utilizing DNA typing methods for biometric purposes. Forensic DNA typing using STR markers has been performed in the criminal

DNA Mixture Interpretation

Ongoing

Based on data collected over the last year from various forensic labs, (see http://www.cstl.nist.gov/biotech/strbase/mixture.htm) the majority of DNA evidence

DNA Profiling Standard Reference Materials

Ongoing

NIST has produced several PCR-based DNA Profiling Standard Reference Materials (SRMs) for the forensic community. The primary uses of these materials are

Ecogenotoxicity Measurements of Nanoparticles

Ongoing

As a result of their novel properties, nanoparticles are expected to be produced and incorporated into consumer products at exponentially increasing quantities

Electronic Biophysical Measurements

Ongoing

Chipscale electronic devices such as field-effect transistors (FETs) are being developed for biochemical applications ranging from clinical diagnostics to

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