Tuesday, April 25, 2000
10:30-11:30 am
Green Auditorium

Cholesterol and Coronary Artery Disease

Howard Kruth, MD
Chief, Section of Experimental Atherosclerosis
National Heart, Lung, and Blood Institute
National Institutes of Health

Cholesterol deposition in the walls of blood vessels begins a complex pathological process called atherosclerosis. Atherosclerosis can eventually lead to blockage of the vessels usually by triggering a blood clot to form. When this process occurs in a coronary artery, the blockage can cause a heart attack. White blood cells (macrophages) respond to the buildup of vessel wall cholesterol. I will discuss mechanisms for cholesterol deposition in arteries and how macrophages function during development of atherosclerotic lesions.