Parallel Synthesis and High-Throughput Characterization of Polyanhydride Random Copolymers for Controlled Drug Delivery Applications

 

Brandon M. Vogel 1, Naomi Eidelman 1,

Surya K. Mallapragada 2, and Balaji Narasimhan 2

Polymers Division, National Institute of Standards of Technology, Gaithersburg MD 20899 1

Department of Chemical Engineering, Iowa State University, Ames, Iowa 50011 2

 

In this age of rapid drug discovery and advances in protein and biomacromolecular therapies, determining the correct copolymer system and composition are of the utmost importance to effectively stabilize a target drug. Considerable interest lies in the efficient synthesis of materials in a high throughput manner for material library screening. A combinatorial library of 100 poly(anhydride) random copolymers was designed, synthesized, and characterized within a few hours. An organic solvent resistant multi-sample substrate array of (10 10) 1 ml wells was fabricated using a rapid prototyping fabrication method. The library was constructed with a liquid dispensing system, consisting of a series of computer-controlled volume dispensing pumps and XYZ motion stages. Copolymers of 1,6-bis(p-carboxyphenoxy)hexane (CPH) and sebacic anhydride (SA) were characterized using infrared microscopy. The copolymer composition is correlated with results from a novel fluorescence based parallel release experiment with a hydrophobic dye. The methodology described in this work is amenable to numerous applications in the arenas of polymer synthesis and characterization.

 

Brandon M. Vogel

NIST Postdoctoral Fellow
National Institute of Standards and Technology
100 Bureau Drive
Gaithersburg, MD 20899-8541, USA
Building 224, Room B314
Tel: (301) 975-6994
Fax: (301) 975-4977

 

Non-Member

Materials

Mentor: Eric K. Lin