Osteoblast Adhesion on 3D Rapid Prototyped Scaffolds

T. Dutta Roy¹, J.J. Stone², W. Sun³, E.H. Cho⁴, S.J. Lockett⁴, F.W. Wang¹, L.A. Henderson¹

¹Biomaterials Group, Polymers Division, MSEL, NIST

²North Dakota State University, Dept. of Mechanical Engineering, Fargo, ND

³Drexel University, Dept. of Mechanical Engineering and Mechanics, Philadelphia, PA

⁴National Cancer Institute, Research Technology Program, Frederick, MD

            While many groups normally perform cell proliferation and differentiation studies on 3D orthopaedic tissue engineering scaffolds, not many have examined expression of cell adhesion molecules in 3D scaffolds compared to 2D surfaces. Examining cell-matrix adhesion interactions in 3D environments can lead to key performance indicators of cell responses that could potentially affect cell migration, proliferation, and differentiation. Rapid prototyping (RP) techniques have successfully produced 3D tissue engineering scaffolds with controlled, reproducible architectures and excellent interconnectivity. Scaffolds fabricated using RP techniques are undergoing extensive characterization to determine their suitability as a reference scaffold for tissue engineering. Here, experimentation focuses primarily on differences in cellular adhesion between 3D RP scaffolds and 2D surfaces.

Post-Doc: Tithi Dutta Roy

Mentor: Francis Wang

Division: Polymers

Laboratory: Materials Science and Engineering Laboratory (MSEL)

Address: Room A107, Building 224

Mail Stop: 8543

Telephone: 6747

Fax: 4977

Email: tithi.duttaroy@nist.gov

Sigma Xi member: No

Category: Biotechnology and Biology, Materials