A new synthetic method for controlled polymerization of HPMA using a microfluidic system

Tao Wu, Chang Xu, João T. Cabral, Kathryn L. Beers

Polymers Division, MSEL


Atom transfer radical polymerizations (ATRP) were performed in a microfluidic channel, fabricated in a solvent resistant polymer matrix. Compared to conventional batch polymerization, microfluidic platforms offer a unique opportunity to handle small samples in high volumes with both time and space control. In our experiments, we show continuous polymerization of hydroxyl propyl methacrylate (HPMA) in the microfluidic channel. We are able to control molecular weight by regulating reaction times using different constant pumping rate. Alternately, we can control input of reagent ratios to control molecular weight, composition and architecture of the polymer output. This method is one piece of a larger platform being designed to formulate polymeric materials using microfluidic technology.


Presenting Author's information

Name  Tao Wu
Division  Polymers
Laboratory  MSEL
Room and Building address  B228 Building 224
Mail Stop  8542
Telephone  975-2836
FAX  975-4924
email  tao.wu@nist.gov
Sigma Xi member?  NO

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