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You searched on: Topic Area: Life Sciences Research

Displaying records 41 to 50 of 151 records.
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41. Plant and fungal Fpg homologs are formamidopyrimidine DNA glycosylases but not 8-oxoguanine DNA glycosylases
Topic: Life Sciences Research
Published: 5/1/2009
Authors: Scott D Kathe, Ramiro Barrantes-Reynolds, Pawel Jaruga, Michael Newton, Cynthia Burrows, Viswanath Bandaru, M Miral Dizdar, Jeffrey Bond, Susan Wallace
Abstract: Formamidopyrimidine DNA glycosylase (Fpg) and endonuclease VIII (Nei) share an overall common three dimensional structure and primary amino acid sequence in conserved structural motifs but have different substrate specificities, with bacterial Fpg pr ...

42. Cell volume distributions reveal cell growth rates and division times
Topic: Life Sciences Research
Published: 3/7/2009
Authors: Michael W Halter, John T Elliott, Joseph Bunton Hubbard, Alessandro Tona, Anne L Plant
Abstract: A population of cells in culture displays a range of phenotypic responses, even when those cells are derived from a single cell and are exposed to a homogeneous environment. Phenotypic variability can have a number of sources, including the variable ...

43. Surface plasmon resonance imaging of cells and surface-associated fibronectin
Topic: Life Sciences Research
Published: 2/26/2009
Authors: Alexander W Peterson, Michael W Halter, Alessandro Tona, Kiran Bhadriraju, Anne L Plant
Abstract: Background A critical challenge in cell biology is quantifying the interactions of cells with their extracellular matrix (ECM) environment and the active remodeling by cells of their ECM. Fluorescence microscopy is a commonly employed technique for ...

44. Accumulation of (5'S)-8,5'-cyclo-2'-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice
Topic: Life Sciences Research
Published: 2/1/2009
Authors: Guldal Kirkali, N de Souza-Pinto, Pawel Jaruga, V. Bohr, M Miral Dizdar
Abstract: Cockayne syndrome (CS) is a human genetic disorder characterized by sensitivity to UV radiation, neurodegeneration, premature aging among other phenotypes. CS complementary group B (CS-B) gene (csb) encodes the CSB protein (CSB) that is involved in b ...

45. Measurement of formamidopyrimidines in DNA
Topic: Life Sciences Research
Published: 12/15/2008
Authors: Pawel Jaruga, Guldal Kirkali, M Miral Dizdar
Abstract: Formamidopyrimidines, 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua), are among major lesions in DNA generated by hydroxyl radical attack, UV radiation or photosensitization in vitro and in vivo. ...

46. Performance of mitochondrial DNA mutations detecting early stage cancer
Topic: Life Sciences Research
Published: 10/3/2008
Authors: J P. Jakupciak, Samantha D Maragh, Maura E Markowitz, Alissa K Greenberg, Mohammad O Hoque, A Maitra, Peter E. Dr. Barker, Paul D Wagner, William N Rom, Sudhir Srivastava, David Sidransky, Catherine D O'Connell

47. Effect of the Distal C162S Mutation on the Energetics of Drug Binding to p38 alpha MAP Kinase
Topic: Life Sciences Research
Published: 1/15/2008
Authors: Niya Todorova, V Doseeva, Jayanthi Ramprakash, Frederick P. Schwarz
Abstract: The binding constant, Kb, and the binding enthalpy (DbHo) of the inhibitor drugs, SB 203580, SKF 86002, and p38 INH.1 binding to two splice variants of p38a MAP kinase and their C162S mutants in 5mM HEPES buffer at pH =7.4 were determined from isoth ...

48. Validation of Novel Optical Imaging Modalities: The Pathologists' View
Topic: Life Sciences Research
Published: 10/1/2007
Authors: W Wells, Peter E. Dr. Barker, C Macaulay, M Novelli, Richard Levenson, J Crawford
Abstract: Recent advances in optical imaging technology have the potential to improve the accuracy of disease detection and predict treatment response. The critical end-point for the success of any new imaging technology is clinical outcome. The following rev ...

49. The Role of Water in the Thermodynamics of Drug Binding to Cyclodextrin
Topic: Life Sciences Research
Published: 7/1/2007
Authors: Niya Tordorova, Frederick P. Schwarz
Abstract: The thermodynamic parameters, DBGo, DBHo, and DBSo, of the drugs flurbiprofen (FLP), nabumetone (NAB), and naproxen (NPX) binding to b-cyclodextrin (bCD) and to g-cyclodextrin (gCD) in 0.10 M sodium phosphate buffer were determined from isothermal ti ...

50. Human Polymorphic Variants of the NEIL1 DNA Glycosylase: Potential Implications for Human Health
Topic: Life Sciences Research
Published: 5/25/2007
Authors: Laura Roy, Pawel Jaruga, Thomas Wood, Amanda K McCullough, M Miral Dizdar, R. Stephen Lloyd
Abstract: In mammalian cells, the repair of DNA bases damaged by reactive oxygen species is primarily initiated by a series of DNA glycosylases that include OGG1, NTH1, NEIL1 and NEIL2. To explore the functional significance of NEIL1, we recently reported tha ...

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