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You searched on: Topic Area: Life Sciences Research

Displaying records 31 to 40 of 145 records.
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31. Substrate specificity and excision kinetics of natural polymorphic variants and phosphomimetic mutants of human 8-oxoguanine-DNA glycosylase
Topic: Life Sciences Research
Published: 9/1/2009
Authors: Viktoriya Sidorenko, Arthur P Grollman, Pawel Jaruga, M Miral Dizdar, Dmitry Zharhov
Abstract: Human 8-oxoguanine-DNA-glycosylase (OGG1) efficiently removes mutagenic 8-oxoguanine (8-oxoGua) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) when paired with cytosine in damaged DNA. Excision of 8-oxoGua mispaired with adenine may lead t ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=902113

32. Combinatorial Screening of Hydrogel Properties for 3-D Cell Culture: Effect of Stiffness on Encapsulated Osteoblasts
Topic: Life Sciences Research
Published: 7/15/2009
Authors: Carl George Simon Jr., Kaushik Chatterjee, Sheng Lin-Gibson, William E Wallace III, Marian F Young
Abstract: A combinatorial method to rapidly screen cell-material interactions in three-dimensional (3-D) culture format was developed for accelerating tissue engineering research. Hydrogels of poly(ethylene glycol) dimethacrylate (PEGDM) with gradients in comp ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=901798

33. Glutathione Depletion by Buthionine Sulfoximine Induces Oxidative Damage to DNA in Organs of Rabbits in vivo
Report Number: 901398
Topic: Life Sciences Research
Published: 6/9/2009
Authors: Goksel Gokce, Gonen Ozsarlak, Gulgun Oktay, Guldal Kirkali, Pawel Jaruga, M Miral Dizdar, Zeliha Kerry
Abstract: Glutathione (GSH) exists in mammalian tissues in vivo at high concentrations and plays an important protective role against oxidatively induced damage to biological molecules including DNA. We investigated oxidatively induced damage to DNA by GSH dep ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=901398

34. Oligo(ethylene oxide) Self-Assembled Monolayers, with Self-limiting Packing Densities for the Inhibition of Nonspecific Protein Adsorption
Topic: Life Sciences Research
Published: 5/5/2009
Authors: David J. Vanderah, Ryan Vierling, Marlon L Walker
Abstract: We have created a molecule that forms self-assembled monolayers (SAMs) on Au possessing the characteristics for inhibition of nonspecific protein adsorption, i.e., uniformly distributed, loosely-packed, conformationally mobile, hydrated ethylene oxid ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=900173

35. Plant and fungal Fpg homologs are formamidopyrimidine DNA glycosylases but not 8-oxoguanine DNA glycosylases
Topic: Life Sciences Research
Published: 5/1/2009
Authors: Scott D Kathe, Ramiro Barrantes-Reynolds, Pawel Jaruga, Michael Newton, Cynthia Burrows, Viswanath Bandaru, M Miral Dizdar, Jeffrey Bond, Susan Wallace
Abstract: Formamidopyrimidine DNA glycosylase (Fpg) and endonuclease VIII (Nei) share an overall common three dimensional structure and primary amino acid sequence in conserved structural motifs but have different substrate specificities, with bacterial Fpg pr ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=900972

36. Cell volume distributions reveal cell growth rates and division times
Topic: Life Sciences Research
Published: 3/7/2009
Authors: Michael W Halter, John T Elliott, Joseph Bunton Hubbard, Alessandro Tona, Anne L Plant
Abstract: A population of cells in culture displays a range of phenotypic responses, even when those cells are derived from a single cell and are exposed to a homogeneous environment. Phenotypic variability can have a number of sources, including the variable ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=832284

37. Surface plasmon resonance imaging of cells and surface-associated fibronectin
Topic: Life Sciences Research
Published: 2/26/2009
Authors: Alexander W Peterson, Michael W Halter, Alessandro Tona, Kiran Bhadriraju, Anne L Plant
Abstract: Background A critical challenge in cell biology is quantifying the interactions of cells with their extracellular matrix (ECM) environment and the active remodeling by cells of their ECM. Fluorescence microscopy is a commonly employed technique for ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=902594

38. Accumulation of (5'S)-8,5'-cyclo-2'-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice
Topic: Life Sciences Research
Published: 2/1/2009
Authors: Guldal Kirkali, N de Souza-Pinto, Pawel Jaruga, V. Bohr, M Miral Dizdar
Abstract: Cockayne syndrome (CS) is a human genetic disorder characterized by sensitivity to UV radiation, neurodegeneration, premature aging among other phenotypes. CS complementary group B (CS-B) gene (csb) encodes the CSB protein (CSB) that is involved in b ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=832387

39. Measurement of formamidopyrimidines in DNA
Topic: Life Sciences Research
Published: 12/15/2008
Authors: Pawel Jaruga, Guldal Kirkali, M Miral Dizdar
Abstract: Formamidopyrimidines, 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua), are among major lesions in DNA generated by hydroxyl radical attack, UV radiation or photosensitization in vitro and in vivo. ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=832358

40. Performance of mitochondrial DNA mutations detecting early stage cancer
Topic: Life Sciences Research
Published: 10/3/2008
Authors: J P. Jakupciak, Samantha D Maragh, Maura E Markowitz, Alissa K Greenberg, Mohammad O Hoque, A Maitra, Peter E. Dr. Barker, Paul D Wagner, William N Rom, Sudhir Srivastava, David Sidransky, Catherine D O'Connell
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=906440



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