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Topic Area: Life Sciences Research

Displaying records 191 to 200 of 266 records.
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191. Oxygen Binding to alpha-Subunits in High-Salt Crystals of T-State Haemoglobin
Topic: Life Sciences Research
Published: 4/1/1999
Authors: G B Vasquez, X Ji, I Pechik, C Fronticelli, G L. Gilliland

192. Effect of Mutations at the Monomer-Monomer Interface of cAMP Receptor Protein on Specific DNA Binding
Topic: Life Sciences Research
Published: 3/12/1999
Authors: Y. Shi, S L Wang, Susan T Krueger, Frederick P. Schwarz
Abstract: To Determine the thermodynamic role of binding of an operon to cAMP receptor protein (CRP) in the activation of transcription, isothermal titration calorimetry measurements were performed on the binding of three 40-base pair DNA sequences to the cycl ...

193. Engineering Receptor-Mediated Cytotoxicity Into Human Ribonucleases by Steric Blockade of Inhibitor Interaction
Topic: Life Sciences Research
Published: 3/1/1999
Authors: M Suzuki, S K Saxena, E Boix, R J Prill, V M Vasandani, Jane E Ladner, C Sung, R J Youle
Abstract: Several nonammalian members of the Rnase A superfamily exhibit anticancer activity that appears to correlate with resistance to the cytosolic ribonuclease inhibitor (RI). We mutated two human ribonucleases-pancreatic Rnase (hRNAse) and eosinophil-de ...

194. Genetically Engineered Metal Ion Binding Sites on the Outside of a Channel's Transmembrane {Beta}-Barrel
Topic: Life Sciences Research
Published: 2/1/1999
Authors: John J Kasianowicz, D L Burden, L C Han, S Cheley, H Bayley
Abstract: We are exploring the ability of genetically engineered versions of the Staphlococcus aureus {alpha}HL} ion channel to serve as rationally designed sensor components for analytes including divalent cations. We show here that neither the hemolytic act ...

195. Electronic Structure and Spectra of Oxovanadium Silicate
Topic: Life Sciences Research
Published: 1/11/1999
Author: Morris Krauss
Abstract: The electronic structure and spectroscopy of the oxovanadium catalytic center on a silica surface is modeled with the molecule OV(OSIH^d3^)3. Excited electronic states are examined at optimized geometries for the ground singlet and triplet states. ...

196. Cysteines beta 93 and beta 112 as Probes of Conformational and Functional Events at the Human Hemoglobin Subunit Interfaces
Topic: Life Sciences Research
Published: 1/1/1999
Authors: G B. Vasquez, M Karavitis, X Ji, I Pechik, W S Brinigar, G L. Gilliland, C Fronticelli
Abstract: Human hemoglobin is a tetrameric protein containing two types of subunits, [alpha] and [Beta]. They assemble forming two different interfaces. The [alpha^d1^[Beta}^d1^ (and [alpha]^d2^[Beta]^d2^) interface stabilize the two dimers and is not modifi ...

197. Self Assembly Driven by Hydrophobic Interaction at Alkanethiol Monolayers: Mechanism of Formation of Hybrid Bilayer Membranes
Topic: Life Sciences Research
Published: 12/14/1998
Authors: J B Hubbard, Vitalii Ivanovich Silin, Anne L Plant

198. Electron Transfer between Surface {?}confined Cytochrome c and an N-acetylcystein-modified Gold Electrode
Topic: Life Sciences Research
Published: 12/8/1998
Authors: T Ruzgas, L S Wong, Adolfas Kastytis Gaigalas, V L. Vilker

199. Differential Scanning Calorimetric Studies of the Glycoprotein, Winged Bean Acidic Lectin, Isolated from the Seeds of Psophocarpus Tetrogonolobus
Topic: Life Sciences Research
Published: 12/1/1998
Authors: V R Srinivasa, N C Singha, F P Schwarzm, A Surolia

200. Mapping Oxidative DNA Damage at Nucleotide Level
Topic: Life Sciences Research
Published: 12/1/1998
Authors: H Rodriguez, S. A. Akman

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