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Topic Area: Drugs/Pharmaceuticals
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Displaying records 41 to 50 of 54 records.
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41. Semantic Web for the Life Sciences Hype, Why, How and Use Case for AIDS Inhibitors
Topic: Drugs/Pharmaceuticals
Published: 7/1/2007
Authors: Talapady N Bhat, John Barkley
Abstract: There is considerable interest in the Semantic Web as a solution to the growing information technology needs of biological data and drug discovery. However, the progress towards this vision has been very limited. One reason for this slow progress is ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830549

42. Solid State Chemistry of Proteins: II. The Correlation of Storage Stability of Freeze-Dried Human Growth Hormone (hGH) With Structure and Dynamics in the Glassy Solid
Topic: Drugs/Pharmaceuticals
Published: 12/1/2008
Authors: Michael Pikal, Daniel Rigsbee, Michael L Roy, Dawn Galreath, Karl J Kovach, Bingquan S. Wang, John F Carpenter, Marcus T Cicerone
Abstract: This research presents storage stability of human growth hormone, hGH, in a variety of lyophilized formulations, including systems of varying sugar:hGH weight ratios for both sucrose and trehalose. Stability was assessed at multiple time points durin ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=852769

43. Standards for the Optical Detection of Protein Particulates
Topic: Drugs/Pharmaceuticals
Published: 1/23/2012
Authors: Dean C Ripple, Michael J Carrier, Joshua R. Wayment
Abstract: Particulates in protein therapeutics, composed of agglomerated protein monomers, may cause an immunogenic response in patients. Consequently, industry and the FDA desire more accurate methods for counting and characterizing particulates. Unlike lik ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=908731

44. Structural Basis for Inactivation of Giardia lamblia Carbamate Kinase by Disulfiram
Topic: Drugs/Pharmaceuticals
Published: 4/11/2014
Authors: Andrey Galkin, Liudmila Kulakova, Kap Lim, Catherine Chen, Wei Zhang, Illarion V Turko, Osnat Herzberg
Abstract: Carbamate kinase from Giardia lamblia is an essential enzyme for the survival of the organism. The enzyme catalyzes the final step in the arginine dihydrolase pathway converting ADP and carbamoyl phosphate to ATP and carbamate. We previously repo ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915235

45. Structural Calcium (Trypsin, Subtilisin)
Topic: Drugs/Pharmaceuticals
Published: Date unknown
Authors: G L. Gilliland, A Teplyakov
Abstract: There are about 40 families of serine proteases defined by amino acid sequence similarities that can be further grouped into 7 clans on the basis of their tertiary structure and the order of the catalytic triad.^u1^ Members of clans SA and SB are c ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830437

46. Study of interaction of the cyclin-dependent kinase 5 with its activator, p25 and with the p25-derived inhibitor, CIP
Series: NIST Interagency/Internal Report (NISTIR)
Report Number: 7552
Topic: Drugs/Pharmaceuticals
Published: 1/15/2009
Authors: Antonio Cardone, Ram D Sriram, Wayne Albers, Harish C. Pant
Abstract: A high-affinity inhibitor protein called CIP, which can be produced by small truncations of p35, was earlier identified by Amin, Albers, and Pant. P35 is one of the physiological activators of cdk5, a member of the cyclin-dependent kinase family. The ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=901184

47. TLR stimulation initiates a CD39-based autoregulatory mechanism that limits macrophage inflammatory responses
Topic: Drugs/Pharmaceuticals
Published: 9/12/2013
Authors: John P Marino, Katharine Therese Briggs, Heather Cohen, Katya Ravid, Simon C. Robson, David M. Mosser
Abstract: Sepsis is a highly fatal disease caused by an initial hyperinflammatory response followed by a state of profound immunosuppression. Although it is well appreciated that the initial production of proinflammatory cytokines by macrophages accompanies th ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=912870

48. Testing for the Antiphospholipid Syndrome: Importance of IgA Anti-beta 2-glycoprotein I
Topic: Drugs/Pharmaceuticals
Published: 12/17/2000
Authors: T.P. Greco, Michael D. Amos, A.M. Conti-Kelly, J.D. Naranjo, J.W. Ijdo
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=901236

49. The Metrology of Counting Protein Particles
Topic: Drugs/Pharmaceuticals
Published: 3/18/2013
Authors: Dean C Ripple, Michael J Carrier, Richard E Cavicchi, Christopher B Montgomery, Zhishang Hu
Abstract: A common degradation pathway for protein-based drugs is the growth of protein aggregates or particles. Counting and characterization of these particles is needed to assure the quality, efficacy, and safety of this type of drug. The unusual physical ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913322

50. The Metrology of Counting Protein Particles
Topic: Drugs/Pharmaceuticals
Published: 7/13/2013
Authors: Dean C Ripple, Michael J Carrier, Richard E Cavicchi, Christopher B Montgomery, Zhishang Hu
Abstract: A common degradation pathway for protein-based drugs is the growth of protein aggregates or particles. Counting and characterization of these particles is needed to assure the quality, efficacy, and safety of this type of drug. The unusual physic ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=916139



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