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Topic Area: Drugs/Pharmaceuticals
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Displaying records 21 to 30 of 33 records.
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21. Protein Particles: What We Know and What We Don’t Know
Topic: Drugs/Pharmaceuticals
Published: 6/26/2012
Authors: Dean C Ripple, Mariana Dimitrova
Abstract: All therapeutic protein products contain particles formed by the aggregation of protein monomers. There is a growing interest in the understanding of particles in biopharmaceutical products, which has been fostered on the one hand by significant ad ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=910991

22. Quantification of Drugs of Abuse in Municipal Wastewater via SPE and Direct Injection Liquid Chromatography Mass Spectrometry
Topic: Drugs/Pharmaceuticals
Published: 9/24/2010
Authors: Michele M Schantz, Katrice A Lippa, Kevin Bisceglia, A. Lynn Roberts
Abstract: We present an isotopic dilution direct injection reverse phase liquid chromatography-tandem mass spectrometry (RPLC/MS/MS) method for the simultaneous determination of 23 drugs of abuse, drug metabolites, and human use markers in municipal wastewater ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=904046

23. Quantifying Dithiothreitol Displacement of Functional Ligands from Gold Nanoparticles
Topic: Drugs/Pharmaceuticals
Published: 10/27/2012
Authors: De-Hao Tsai, Frank W DelRio, Sherrie R. Elzey, Suvajyoti S. Guha, Michael Russel Zachariah, Vincent A Hackley, Melanie P Shelton
Abstract: Dithiothreitol (DTT)-based displacement is widely utilized for separating ligands from their gold nanoparticle (AuNP) conjugates, a critical step for differentiating and quantifying surface-bound functional ligands and therefore the effective surface ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=911354

24. Quantitation of HER2 and Telomerase Biomarkers in Solid Tumors with IgY Antibodies and Nanocrystal Detection
Topic: Drugs/Pharmaceuticals
Published: 5/15/2008
Authors: Yan Xiao, X Gao, G Gannot, M Emmert-Buck, S Srivastava, Paul D Wagner, Michael D. Amos, Peter E. Dr. Barker
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=901234

25. Semantic Web for the Life Sciences Hype, Why, How and Use Case for AIDS Inhibitors
Topic: Drugs/Pharmaceuticals
Published: 7/1/2007
Authors: Talapady N Bhat, John Barkley
Abstract: There is considerable interest in the Semantic Web as a solution to the growing information technology needs of biological data and drug discovery. However, the progress towards this vision has been very limited. One reason for this slow progress is ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830549

26. Solid State Chemistry of Proteins: II. The Correlation of Storage Stability of Freeze-Dried Human Growth Hormone (hGH) With Structure and Dynamics in the Glassy Solid
Topic: Drugs/Pharmaceuticals
Published: 12/1/2008
Authors: Michael Pikal, Daniel Rigsbee, Michael L Roy, Dawn Galreath, Karl J Kovach, Bingquan S. Wang, John F Carpenter, Marcus T Cicerone
Abstract: This research presents storage stability of human growth hormone, hGH, in a variety of lyophilized formulations, including systems of varying sugar:hGH weight ratios for both sucrose and trehalose. Stability was assessed at multiple time points durin ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=852769

27. Standards for the Optical Detection of Protein Particulates
Topic: Drugs/Pharmaceuticals
Published: 1/23/2012
Authors: Dean C Ripple, Michael J Carrier, Joshua R. Wayment
Abstract: Particulates in protein therapeutics, composed of agglomerated protein monomers, may cause an immunogenic response in patients. Consequently, industry and the FDA desire more accurate methods for counting and characterizing particulates. Unlike lik ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=908731

28. Structural Calcium (Trypsin, Subtilisin)
Topic: Drugs/Pharmaceuticals
Published: Date unknown
Authors: G L. Gilliland, A Teplyakov
Abstract: There are about 40 families of serine proteases defined by amino acid sequence similarities that can be further grouped into 7 clans on the basis of their tertiary structure and the order of the catalytic triad.^u1^ Members of clans SA and SB are c ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830437

29. Study of interaction of the cyclin-dependent kinase 5 with its activator, p25 and with the p25-derived inhibitor, CIP
Series: NIST Interagency/Internal Report (NISTIR)
Report Number: 7552
Topic: Drugs/Pharmaceuticals
Published: 1/15/2009
Authors: Antonio Cardone, Ram D Sriram, Wayne Albers, Harish C. Pant
Abstract: A high-affinity inhibitor protein called CIP, which can be produced by small truncations of p35, was earlier identified by Amin, Albers, and Pant. P35 is one of the physiological activators of cdk5, a member of the cyclin-dependent kinase family. The ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=901184

30. Testing for the Antiphospholipid Syndrome: Importance of IgA Anti-beta 2-glycoprotein I
Topic: Drugs/Pharmaceuticals
Published: 12/17/2000
Authors: T.P. Greco, Michael D. Amos, A.M. Conti-Kelly, J.D. Naranjo, J.W. Ijdo
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=901236