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Topic Area: Drugs/Pharmaceuticals
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Displaying records 21 to 30 of 52 records.
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21. Evaluation of viability and proliferation profiles on macrophages treated with silica nanoparticles in vitro via plate-based, flow cytometry, and Coulter counter assays
Topic: Drugs/Pharmaceuticals
Published: 9/3/2012
Authors: Simona Bancos, De-Hao D. Tsai, Vincent A Hackley, J L Weaver, Katherine M Tyner
Abstract: Nanoparticles (NPs) are known to interfere with many high throughput cell viability and cell proliferation assays, which complicates the assessment of their potential toxic effects. The aim of this study was to compare viability and proliferation res ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=911765

22. Monte Carlo and dynamics simulations of cdk5 Kinase inhibitor peptides p5 in aqueous solution
Topic: Drugs/Pharmaceuticals
Published: 7/20/2012
Authors: Antonio Cardone, Sergio Hassan, Mary C Brady, Ram D Sriram, Harish C. Pant
Abstract: Protein function depends on shape changes that are triggered by interactions with other molecules. Insights into protein dynamics and interactions enable the understanding of certain pathologies, which may be caused by the deregulation of protein ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=911466

23. Protein Particles: What We Know and What We Don‰t Know
Topic: Drugs/Pharmaceuticals
Published: 6/26/2012
Authors: Dean C Ripple, Mariana Dimitrova
Abstract: All therapeutic protein products contain particles formed by the aggregation of protein monomers. There is a growing interest in the understanding of particles in biopharmaceutical products, which has been fostered on the one hand by significant ad ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=910991

24. Probing the Nature of Ibuprofen Confined in Mesoporous Media by Neutron Vibrational Spectroscopy and First-Principles Calculations
Topic: Drugs/Pharmaceuticals
Published: 5/15/2012
Author: Ken Kangyi Qian
Abstract: {B}Purpose{/B}: In this paper, the nature of ibuprofen incorporated into both mesoporous silicon dioxide and magnesium aluminometasilicate by sublimation and adsorption was investigated using neutron vibrational spectroscopy. {B}Methods{/B}: Crystall ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=910370

25. A Lectin-Based Gold Nanoparticle Assay for Probing Glycosylation of Glycoproteins
Topic: Drugs/Pharmaceuticals
Published: 4/17/2012
Authors: Germarie Sanchez-Pomales, Todd A. Morris, James Falabella, Michael J Tarlov, Rebecca A Zangmeister
Abstract: We report a glycoanalysis method in which lectins are used to probe the glycans of glycoproteins that are adsorbed on gold nanoparticles. A model mannose-presenting glycoprotein, ribonuclease B (RNase B), and the therapeutic monoclonal antibody (mAb) ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=909549

26. Tumor Necrosis Factor Interaction with Gold Nanoparticles
Topic: Drugs/Pharmaceuticals
Published: 3/14/2012
Authors: De-Hao D. Tsai, Sherrie R. Elzey, Frank W DelRio, Robert I. MacCuspie, Suvajyoti S. Guha, Michael Russel Zachariah, Athena M Keene, Jeffrey D Clogston, Vincent A Hackley
Abstract: We report on a systematic investigation of molecular conjugation of tumor necrosis factor protein-α (TNF) onto gold nanoparticles (AuNPs) and the subsequent binding behavior to its antibody (anti-TNF). We employ a combination of physical and spe ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=909899

27. Standards for the Optical Detection of Protein Particulates
Topic: Drugs/Pharmaceuticals
Published: 1/23/2012
Authors: Dean C Ripple, Michael J Carrier, Joshua R. Wayment
Abstract: Particulates in protein therapeutics, composed of agglomerated protein monomers, may cause an immunogenic response in patients. Consequently, industry and the FDA desire more accurate methods for counting and characterizing particulates. Unlike lik ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=908731

28. Predictive Gold Nanocluster Formation Controlled by Metal-Ligand Complexes
Topic: Drugs/Pharmaceuticals
Published: 1/9/2012
Authors: John M Pettibone, Jeffrey W Hudgens
Abstract: The formation of ligand-protected transition metal nanoclusters in size-selective syntheses is driven by the inherent properties of the protecting ligands. We have previously reported the selective, monodisperse product formation of phosphine protect ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=908225

29. A Streamlined Hydrolysis Procedure for the LC/MS/MS Analysis of Cocaine in Wastewater Samples
Topic: Drugs/Pharmaceuticals
Published: 1/2/2012
Authors: Katrice A Lippa, Kevin Bisceglia, A. Lynn Roberts
Abstract: We report a streamlined procedure for the routine analysis of cocaine in municipal wastewater. By adding NaOH (to 0.025 M) and incubating wastewater samples at 55 °C for two hours, cocaine and its principal metabolites are quantitatively converted i ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=903657

30. Recent Advances in Electrochemical Glyco-biosensing
Topic: Drugs/Pharmaceuticals
Published: 4/8/2011
Authors: Rebecca A Zangmeister, Germarie Sanchez-Pomales
Abstract: Biosensors based on electrochemical transduction mechanisms have recently made advances into the field of glycan analysis. These glyco-biosensor assays offer simple, rapid, sensitive and economical approaches to the measurement need for rapid glycan ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=908197



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