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Topic Area: Drugs/Pharmaceuticals
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Displaying records 11 to 20 of 48 records.
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11. The Metrology of Counting Protein Particles
Topic: Drugs/Pharmaceuticals
Published: 3/18/2013
Authors: Dean C Ripple, Michael J Carrier, Richard E Cavicchi, Christopher B Montgomery, Zhishang Hu
Abstract: A common degradation pathway for protein-based drugs is the growth of protein aggregates or particles. Counting and characterization of these particles is needed to assure the quality, efficacy, and safety of this type of drug. The unusual physical ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913322

12. Modification of tethered bilayers by phospholipid exchange with vesicles
Topic: Drugs/Pharmaceuticals
Published: 2/27/2013
Authors: David J Vanderah, Rima Budvytyte, Mindaugas Mickevicius, Gintaras Valincius, Frank Heinrich
Abstract: Phosphatidylcholine and cholesterol exchange between vesicles and planar tethered bilayer lipid membranes (tBLMs) was demonstrated from electrochemical impedance spectroscopy (EIS), fluorescence microscopy (FM), and neutron reflectometry (NR) data. ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=912490

13. Breast Cancer Biomarker Measurements and Standards
Topic: Drugs/Pharmaceuticals
Published: 1/24/2013
Authors: Kenneth D Cole, Lili Wang, Hua-Jun He
Abstract: Cancer is a heterogeneous disease characterized by changes in the levels and activities of important cellular proteins, including oncogenes and tumor suppressors. Genetic mutations cause changes in protein activity and protein expression levels that ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=912867

14. NIST/NIH Vitamin D Metabolites Quality Assurance Program Report of Participant Results: Summer 2011 Exercise (Exercise 4)
Series: NIST Interagency/Internal Report (NISTIR)
Report Number: 7893
Topic: Drugs/Pharmaceuticals
Published: 12/21/2012
Authors: Katrice A Lippa, Mary Bedner, Susan Shu Cheng Tai
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=911154

15. NIST/NIH Vitamin D Metabolites Quality Assurance Program Report of Participant Results:Summer 2010 (Exercise 2)
Series: NIST Interagency/Internal Report (NISTIR)
Report Number: 7891
Topic: Drugs/Pharmaceuticals
Published: 12/21/2012
Authors: Katrice A Lippa, Mary Bedner, Susan Shu Cheng Tai
Abstract: The National Institute of Standards and Technology (NIST) recently established a Vitamin D Metabolites Quality Assurance Program (VitDQAP) in collaboration with the National Institutes of Health (NIH) Office of Dietary Supplements. Participants ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=911153

16. Quantifying Dithiothreitol Displacement of Functional Ligands from Gold Nanoparticles
Topic: Drugs/Pharmaceuticals
Published: 10/27/2012
Authors: De-Hao D. Tsai, Frank W DelRio, Sherrie R. Elzey, Suvajyoti S. Guha, Michael Russel Zachariah, Vincent A Hackley, Melanie P Shelton
Abstract: Dithiothreitol (DTT)-based displacement is widely utilized for separating ligands from their gold nanoparticle (AuNP) conjugates, a critical step for differentiating and quantifying surface-bound functional ligands and therefore the effective surface ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=911354

17. Evaluation of viability and proliferation profiles on macrophages treated with silica nanoparticles in vitro via plate-based, flow cytometry, and Coulter counter assays
Topic: Drugs/Pharmaceuticals
Published: 9/3/2012
Authors: Simona Bancos, De-Hao D. Tsai, Vincent A Hackley, J L Weaver, Katherine M Tyner
Abstract: Nanoparticles (NPs) are known to interfere with many high throughput cell viability and cell proliferation assays, which complicates the assessment of their potential toxic effects. The aim of this study was to compare viability and proliferation res ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=911765

18. Monte Carlo and dynamics simulations of cdk5 Kinase inhibitor peptides p5 in aqueous solution
Topic: Drugs/Pharmaceuticals
Published: 7/20/2012
Authors: Antonio Cardone, Sergio Hassan, Mary C Brady, Ram D Sriram, Harish C. Pant
Abstract: Protein function depends on shape changes that are triggered by interactions with other molecules. Insights into protein dynamics and interactions enable the understanding of certain pathologies, which may be caused by the deregulation of protein ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=911466

19. Protein Particles: What We Know and What We Don‰t Know
Topic: Drugs/Pharmaceuticals
Published: 6/26/2012
Authors: Dean C Ripple, Mariana Dimitrova
Abstract: All therapeutic protein products contain particles formed by the aggregation of protein monomers. There is a growing interest in the understanding of particles in biopharmaceutical products, which has been fostered on the one hand by significant ad ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=910991

20. Probing the Nature of Ibuprofen Confined in Mesoporous Media by Neutron Vibrational Spectroscopy and First-Principles Calculations
Topic: Drugs/Pharmaceuticals
Published: 5/15/2012
Author: Ken Kangyi Qian
Abstract: {B}Purpose{/B}: In this paper, the nature of ibuprofen incorporated into both mesoporous silicon dioxide and magnesium aluminometasilicate by sublimation and adsorption was investigated using neutron vibrational spectroscopy. {B}Methods{/B}: Crystall ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=910370



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