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You searched on: Topic Area: Drugs/Pharmaceuticals

Displaying records 11 to 20 of 34 records.
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11. Breast Cancer Biomarker Measurements and Standards
Topic: Drugs/Pharmaceuticals
Published: 1/24/2013
Authors: Kenneth D Cole, Lili Wang, Hua-Jun He
Abstract: Cancer is a heterogeneous disease characterized by changes in the levels and activities of important cellular proteins, including oncogenes and tumor suppressors. Genetic mutations cause changes in protein activity and protein expression levels that ...

12. NIST/NIH Vitamin D Metabolites Quality Assurance Program Report of Participant Results: Summer 2011 Exercise (Exercise 4)
Series: NIST Interagency/Internal Report (NISTIR)
Report Number: 7893
Topic: Drugs/Pharmaceuticals
Published: 12/21/2012
Authors: Katrice A Lippa, Mary Bedner, Susan Shu Cheng Tai

13. NIST/NIH Vitamin D Metabolites Quality Assurance Program Report of Participant Results:Summer 2010 (Exercise 2)
Series: NIST Interagency/Internal Report (NISTIR)
Report Number: 7891
Topic: Drugs/Pharmaceuticals
Published: 12/21/2012
Authors: Katrice A Lippa, Mary Bedner, Susan Shu Cheng Tai
Abstract: The National Institute of Standards and Technology (NIST) recently established a Vitamin D Metabolites Quality Assurance Program (VitDQAP) in collaboration with the National Institutes of Health (NIH) Office of Dietary Supplements. Participants ...

14. Quantifying Dithiothreitol Displacement of Functional Ligands from Gold Nanoparticles
Topic: Drugs/Pharmaceuticals
Published: 10/27/2012
Authors: De-Hao D. Tsai, Frank W DelRio, Sherrie R. Elzey, Suvajyoti S. Guha, Michael Russel Zachariah, Vincent A Hackley, Melanie P Shelton
Abstract: Dithiothreitol (DTT)-based displacement is widely utilized for separating ligands from their gold nanoparticle (AuNP) conjugates, a critical step for differentiating and quantifying surface-bound functional ligands and therefore the effective surface ...

15. Evaluation of viability and proliferation profiles on macrophages treated with silica nanoparticles in vitro via plate-based, flow cytometry, and Coulter counter assays
Topic: Drugs/Pharmaceuticals
Published: 9/3/2012
Authors: Simona Bancos, De-Hao D. Tsai, Vincent A Hackley, J L Weaver, Katherine M Tyner
Abstract: Nanoparticles (NPs) are known to interfere with many high throughput cell viability and cell proliferation assays, which complicates the assessment of their potential toxic effects. The aim of this study was to compare viability and proliferation res ...

16. Probing the Nature of Ibuprofen Confined in Mesoporous Media by Neutron Vibrational Spectroscopy and First-Principles Calculations
Topic: Drugs/Pharmaceuticals
Published: 5/15/2012
Author: Ken Kangyi Qian
Abstract: {B}Purpose{/B}: In this paper, the nature of ibuprofen incorporated into both mesoporous silicon dioxide and magnesium aluminometasilicate by sublimation and adsorption was investigated using neutron vibrational spectroscopy. {B}Methods{/B}: Crystall ...

17. A Lectin-Based Gold Nanoparticle Assay for Probing Glycosylation of Glycoproteins
Topic: Drugs/Pharmaceuticals
Published: 4/17/2012
Authors: Germarie Sanchez-Pomales, Todd A. Morris, James Falabella, Michael J Tarlov, Rebecca A Zangmeister
Abstract: We report a glycoanalysis method in which lectins are used to probe the glycans of glycoproteins that are adsorbed on gold nanoparticles. A model mannose-presenting glycoprotein, ribonuclease B (RNase B), and the therapeutic monoclonal antibody (mAb) ...

18. Tumor Necrosis Factor Interaction with Gold Nanoparticles
Topic: Drugs/Pharmaceuticals
Published: 3/14/2012
Authors: De-Hao D. Tsai, Sherrie R. Elzey, Frank W DelRio, Robert I. MacCuspie, Suvajyoti S. Guha, Michael Russel Zachariah, Athena M Keene, Jeffrey D Clogston, Vincent A Hackley
Abstract: We report on a systematic investigation of molecular conjugation of tumor necrosis factor protein-α (TNF) onto gold nanoparticles (AuNPs) and the subsequent binding behavior to its antibody (anti-TNF). We employ a combination of physical and spe ...

19. Standards for the Optical Detection of Protein Particulates
Topic: Drugs/Pharmaceuticals
Published: 1/23/2012
Authors: Dean C Ripple, Michael J Carrier, Joshua R. Wayment
Abstract: Particulates in protein therapeutics, composed of agglomerated protein monomers, may cause an immunogenic response in patients. Consequently, industry and the FDA desire more accurate methods for counting and characterizing particulates. Unlike lik ...

20. Predictive Gold Nanocluster Formation Controlled by Metal-Ligand Complexes
Topic: Drugs/Pharmaceuticals
Published: 1/9/2012
Authors: John M Pettibone, Jeffrey W Hudgens
Abstract: The formation of ligand-protected transition metal nanoclusters in size-selective syntheses is driven by the inherent properties of the protecting ligands. We have previously reported the selective, monodisperse product formation of phosphine protect ...

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