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You searched on: Topic Area: Biomaterials Sorted by: date

Displaying records 41 to 50 of 66 records.
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41. Effect of offset values of solid freeform fabricated PCL/ß-TCP scaffolds on mechanical properties and cellular activities in bone tissue regeneration
Topic: Biomaterials
Published: 11/1/2012
Authors: Carl George Simon Jr., GeunHyung Kim, MyungGu Yo
Abstract: Microstructures of biomedical scaffolds can greatly affect cellular activities in tissue regeneration. In particular, scaffolds used in bone tissue regeneration should have several microstructural characteristics, including high porosity, appropriate ...

Topic: Biomaterials
Published: 10/28/2012
Authors: Conni Hanke, Petra S. Dittrich, Darwin R Reyes-Hernandez
Abstract: A cell co-culture was generated on opposite sides of a permeable polyester membrane (PET) membrane by combining dielectrophoretic (DEP) and electrostatic forces to hold cells against gravity in a multilayer microfluidic device (Figure 1). HepG2 cell ...

43. Effect of Polymer Degree of Conversion on Streptococcus mutans Biofilms
Topic: Biomaterials
Published: 10/5/2012
Authors: Alison M. Kraigsley, Kathy Tang, John A. Howarter, Katrice A Lippa, Sheng Lin-Gibson, Nancy J Lin
Abstract: The effects of key material properties of polymeric composite restorations on cariogenic oral biofilms are needed to provide insight into the materials‰ role in recurrent caries. The objective of this study was to quantify the effects of degree of co ...

44. Optimization of Imaging Polymer Based Scaffolds Using X-Ray Microcomputed Tomography
Topic: Biomaterials
Published: 5/15/2012
Authors: David E, Morris, Melissa L Mather, Carl George Simon Jr., John A Crowe
Abstract: The performance of polymer based scaffolds used in regenerative medicine is linked to their structural properties and as such strategies for structural characterization of scaffolds have been developed. X-ray microscopic computed tomography (X-ray ...

45. Gas-Foamed Scaffold Gradients for Combinatorial Screening in 3D
Topic: Biomaterials
Published: 5/1/2012
Authors: Carl George Simon Jr., Kaushik Chatterjee, Alison M. Kraigsley, Joachim Kohn, Durgadas Bolikal
Abstract: Current methods for screening cell-material interactions typically utilize two-dimensional (2D) culture format where cells are cultured on flat surfaces. However, there is a need for combinatorial and high-throughput screening methods to systematica ...

46. Osteoblast Response to Serum Protein Adsorption in 3D Polymer Scaffolds
Topic: Biomaterials
Published: 5/1/2012
Authors: Carl George Simon Jr., Girish Kumar, Kaushik Chatterjee, Stevephen Hung
Abstract: Protein adsorption is known to direct biological response to biomaterials and is important in determining cellular response in tissue scaffolds. In this study we investigated the effect of adsorbed serum proteins on cell attachment and proliferation ...

47. Nano-Apatitic Composite Scaffolds for Stem Cell Delivery and Bone Tissue Engineering
Topic: Biomaterials
Published: 4/15/2012
Authors: Hockin H. K. Xu, Carl George Simon Jr.
Abstract: The need for bone defect repair and regeneration arises from trauma, disease, congenital deformity, and tumor resection. Bone fracture occurs to seven million people each year in the United States, and musculoskeletal conditions cost $215 billion ann ...

48. Freeform Fabricated Scaffolds with Roughened Struts that Enhance both Stem Cell Proliferation and Differentiation by Controlling Cell Shape
Topic: Biomaterials
Published: 3/1/2012
Authors: Girish Kumar, Carl George Simon Jr., Michael S. (Michael Stephan) Waters, Tanya M. Farooque, Marian F Young
Abstract: We demonstrate that imparting freeform fabricated (FFF) scaffolds with surface roughness on their struts enhances osteogenic differentiation of primary human bone marrow stromal cells (hBMSCs) by controlling cell shape. Previous work showed that hBM ...

49. Morphological Changes Driven by Nanofibrous Scaffolds Induce Marrow Stromal Cell Osteogenesis
Topic: Biomaterials
Published: 10/11/2011
Authors: Carl George Simon Jr., Kaushik Chatterjee, Christopher K. Tison, Girish Kumar, Patrick S Pine, Marc L Salit, Jennifer H McDaniel, Marian F Young
Abstract: Cells are sensitive to tissue scaffold architecture and these cell-material interactions drive cell functions critical in tissue regeneration. Results presented here demonstrate that nanofiber scaffolds force primary human bone marrow stromal cells ...

50. Hybrid Cell Adhesive Material for Instant Dielectrophoretic Cell Trapping and Long Term Cell Function Assessment
Topic: Biomaterials
Published: 8/16/2011
Authors: Darwin R Reyes-Hernandez, Jennifer S. Hong, John T Elliott, Michael Gaitan
Abstract: We present the development and evaluation of an engineered hybrid cell adhesive surface for instant dielectrophoretic trapping and patterning of cells in a microfluidic device. This work demonstrates that a hybrid cell adhesive material (hCAM) prepar ...

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