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Author: Wyatt Vreeland

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1. Microfluidic Remote Loading for Rapid Single-Step Liposomal Drug Preparation
Published: 7/29/2014
Authors: Wyatt N Vreeland, Renee R Hood, Don L. DeVoe
Abstract: Here we report a microfluidic system that enables rapid and efficient remote loading of amphipathic drugs into nanoscale liposomes, combining liposome synthesis and remote drug loading in a continuous integrated process. Unlike established bulk m ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915563

2. A Facile Route to the Synthesis of Monodisperse Nanoscale Liposomes Using 3D Microfluidic Hydrodynamic Focusing in a Concentric Capillary Array
Published: 5/14/2014
Authors: Wyatt N Vreeland, Renee R Hood, Don L. DeVoe, Francisco Javier Atencia, Donna M. Omiatek
Abstract: A novel microscale device has been developed to enable the one-step continuous flow assembly of monodisperse nanoscale liposomes using three-dimensional microfluidic hydrodynamic focusing (3D-MHF) in a radially symmetric capillary array. The 3D-M ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915562

3. Microfluidic-Enabled of Liposomes Elucidate Size-Dependent Transdermal Transport
Published: 3/21/2014
Authors: Wyatt N Vreeland, Renee R Hood, Eric Kendall, Don L. DeVoe, Julia Finkel, Mariana Junqueira, Zenaide Quezado
Abstract: Microfluidic synthesis of small and nearly-monodisperse liposomes is used to investigate the size-dependent passive transdermal transport of nanoscale lipid vesicles. While large liposomes with diameters above 105 nm are found to be excluded from dee ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915017

4. Microfluidic preparation of liposomes to determine particle size influence on cellular uptake mechanisms
Published: 10/3/2013
Authors: Wyatt N Vreeland, Abhay U Andar, Renee R Hood, Don L. DeVoe, Peter W Swaan
Abstract: Purpose: This study investigates the cellular uptake and trafficking of liposomes in Caco-2 cells, using vesicles with distinct average diameters ranging from 40 nm-276 nm. Liposomes were prepared by microfluidic hydrodynamic flow focusing, producing ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913538

5. Microfluidic Synthesis of Nano-Liposomal Anesthetics
Published: 5/12/2013
Authors: Wyatt N Vreeland, Renee R Hood, Eric Kendall, Mariana Junqueira, Julia Finkel, Don L. DeVoe
Abstract: Topical anesthesia has the ability to provide painless application of pain management medications for minor procedures such as venipuncture, particularly in the pediatric population. Liposomes have been proposed as a highly advantageous nanocarrier f ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913770

6. A rapid, low-cost preparation of monodisperse niosomes in a microfluidic platform
Published: 6/1/2010
Authors: Catherine T. Lo, Andreas Jahn, Wyatt N Vreeland, Laurie E Locascio
Abstract: Niosomes are synthetic membrane vesicles made of self-assembled non-ionic surfactants (i.e. amphiphilic organic compounds). They bear the same properties as liposomes, namely having an aqueous interior that is separated from the exterior aqueous env ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=904028

7. Microfluidic Mixing and the Formation of Nanoscale Lipid Vesicles
Published: 4/27/2010
Authors: Andreas Jahn, Samuel M Stavis, Jennifer S. Hong, Wyatt N Vreeland, Don L DeVoe, Michael Gaitan
Abstract: We investigate the formation of unilamellar lipid vesicles (liposomes) with diameters of tens of nanometers by microfluidic hydrodynamic focusing (MHF). Our study includes liposome synthesis experiments and numerical modeling of our microfluidic imp ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=901576

8. Effects of temperature, acyl chain length, and flow-rate ratio on liposome formation and size in a microfluidic hydrodyanmic focusing device
Published: 3/21/2010
Authors: Justin M Zook, Wyatt N Vreeland
Abstract: Microfluidic hydrodynamic focusing of an alcohol/lipid mixture into a narrow fluid stream by two oblique buffer streams provides a controlled and reproducible method of forming phospholipid bilayer vesicles (i.e., liposomes) with relatively monodispe ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=903474

9. Accurate optical analysis of single molecule entrapment in nanoscale vesicles
Published: 1/1/2010
Authors: Joseph E. (Joseph E.) Reiner, Andreas Jahn, Samuel M Stavis, Michael J Culbertson, Wyatt N Vreeland, Daniel L Burden, Jon C Geist, Michael Gaitan
Abstract: We present a non-destructive method to characterize low analyte concentrations in nanometer scale lipid vesicle formulations. Our method is based on the application of fluorescence fluctuation analysis (FFA) and multi-angle laser light scattering (M ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=902169

10. Magnetic connectors for microfluidic applications
Published: 1/1/2010
Authors: Francisco Javier Atencia, Gregory A Cooksey, Andreas Jahn, Justin M Zook, Wyatt N Vreeland, Laurie E Locascio
Abstract: We present a new type of connector based on a simple idea: using a ring magnet on one side of the microfluidic chip and a disc magnet on the other side to provide the interfacial force necessary to provide a sealed connection between tubing or needle ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=903395



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