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Author: Pawel Jaruga

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1. Significant disparity in base and sugar damage in DNA by neutron and electron irradiation
Published: 7/1/2014
Authors: Pawel Jaruga, Jeffrey S Nico, Lisa R Karam, Olga Timofeeva, William Blakely, M Miral Dizdar, D Pang
Abstract: In this study a comparison of the effects of high-LET neutrons with low-LET electrons on irradiation of aqueous DNA solutions was investigated to characterize for potential neutron signatures on DNA damage induction. Ionizing radiations generate ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915234

2. Quantitative Assessment of Nanoparticle Induced Oxidative Damage to DNA Using Isotope Dilution Mass Spectrometry
Published: 6/16/2014
Authors: Elijah J Petersen, Pawel Jaruga, M Miral Dizdar, Bryant C Nelson
Abstract: Mass spectrometry techniques have been employed as one of the primary analytical tools for investigating the effects of oxygen-derived free radicals on the induction and subsequent repair of oxidatively-induced DNA damage in living systems. The Natio ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915778

3. Inhibition of DNA glycosylases via small molecule purine analogs
Published: 12/9/2013
Authors: M Miral Dizdar, Aaron C. Jacobs, Ajit Jadhav, Dorjbal Dorjsuren, David Maloney, Anton Simeonov, Pawel Jaruga, Amanda K. McCullough, R. Stephen Lloyd
Abstract: Following the formation of oxidatively-induced DNA damage, several DNA glycosylases are required to initiate repair of the base lesions that are formed. Recently, NEIL1 and other DNA glycosylases, including OGG1 and NTH1 were identified as potent ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=914071

4. Identification and Quantification of DNA Repair Protein Apurinic/Apyrimidinic Endonuclease 1 (APE1) in Human Cells by Liquid Chromatography/Isotope-Dilution Tandem Mass Spectrometry
Published: 7/29/2013
Authors: Guldal Kirkali, Pawel Jaruga, Prasad T Reddy, Alessandro Tona, Li Mengxia, David M. Wison III, M Miral Dizdar, Bryant C Nelson
Abstract: Unless repaired, DNA damage can drive mutagenesis or cell death. DNA repair proteins may therefore be used as biomarkers in disease detection or therapeutic response estimation. Thus, the accurate measurement of DNA repair protein expression is of fu ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913457

5. Tools and Approaches for the Assessment of Nanomaterial Induced Oxidative DNA Damage
Published: 5/13/2013
Authors: Elijah J Petersen, Bryce Marquis, Pawel Jaruga, M Miral Dizdar, Bryant C Nelson
Abstract: Hyphenated mass spectrometry techniques have been employed as one of the primary analytical tools for investigating the effects of ionizing radiation, chemical/biological carcinogens, and oxygen derived free radicals on the induction and subsequent r ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913562

6. Identification and Quantification of Human DNA Repair Protein NEIL1 by Liquid Chromatography/Isotope-Dilution Tandem Mass Spectrometry
Published: 12/26/2012
Authors: M Miral Dizdar, Pawel Jaruga, Guldal Kirkali, Bryant C Nelson, Gamze Tuna, Prasad T Reddy
Abstract: Accumulated evidence points to DNA repair capacity as an important factor in cancer and other diseases. DNA repair proteins are promising drug targets and are emerging as prognostic and therapeutic biomarkers. Thus, the knowledge of the overexpressio ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913458

7. Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine.
Published: 7/11/2012
Authors: M Miral Dizdar, Pawel Jaruga, Susan Duclos, Pierre Aller, Susan Wallace, Susan Doublie
Abstract: Formamidopyrimidine-DNA glycosylase (Fpg; MutM) is a DNA repair enzyme widely distributed in bacteria. Fpg recognizes and excises oxidatively modified purines, 4,6-diamino-5-formamidopyrimidine, 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 8-oxogu ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=911417

8. Tools and Approaches for the Assessment of Nanomaterial Induced Oxidative DNA Damage
Published: 6/20/2012
Authors: Elijah J Petersen, Bryce J. Marquis, Pawel Jaruga, M Miral Dizdar, Bryant C Nelson
Abstract: Hyphenated mass spectrometry techniques have been employed as one of the primary analytical tools for investigating the effects of ionizing radiation, chemical/biological carcinogens, and oxygen derived free radicals on the induction and subsequent r ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=911145

9. Identification and quantification of DNA repair proteins by liquid chromatography/isotope-dilution tandem mass spectrometry using 15N-labeled whole proteins as internal standards
Published: 5/30/2012
Authors: M Miral Dizdar, Prasad T Reddy, Guldal Kirkali, Gamze Tuna, Bryant C Nelson, Pawel Jaruga
Abstract: Oxidatively induced DNA damage is implicated in disease, unless it is repaired by DNA repair. DNA repair proteins may be used as early detection and therapeutic biomarkers in cancer and other diseases. For this purpose, the measurement of the exp ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=907830

10. Mechanisms of free radical-induced damage to DNA
Published: 4/1/2012
Authors: M Miral Dizdar, Pawel Jaruga
Abstract: Endogenous and exogenous sources cause free radical-induced DNA damage in living organisms by a variety of mechanisms. The highly reactive hydroxyl radical reacts with the heterocyclic DNA bases and the sugar moiety near or at diffusion-controlled ra ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=910258



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