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1. Detection and characterization of nonspecific, sparsely-populated binding modes for conformational selection in the early stages of complexation
Antonio Cardone, Aaron Bornstein, Harish C. Pant, Mary C Brady, Ram D Sriram, Sergio Hassan
A method is proposed to study protein-ligand binding in a system governed by specific and non-specific interactions. Strong associations lead to narrow conformational distributions in the proteins configuration space; weak and ultra-weak associations ...
2. Ontology for Big Systems: The Ontology Summit 2012 Communique
Ram D Sriram, Mary C Brady
The Ontology Summit 2012 explored the current and potential uses of ontology, its methods and paradigms, in big systems and big data: How ontology can be used to design, develop, and operate such systems. The systems addressed were not just software ...
3. A Vision of Cyber-Physical Cloud Computing for Smart Networked Systems
NIST Interagency/Internal Report (NISTIR)
Eric D Simmon, Kyoung-sook Kim, Eswaran Subrahmanian, Ryong Lee, Frederic Jean Marie de Vaulx, Yohei Murakami, Koji Zettsu, Ram D Sriram
A key aspect of the next generation Smart Networked System (SNS) is the bridge between the physical and virtual world. These systems that tightly interlink the cyber and physical worlds are often referred to as Cyber-Physical Systems (CPS).
A CPS is ...
4. A General Conformance Testing Framework for IEEE 11073 PHD's Communication Model
Raghu N Kacker, Linbin Yu, Yu Lei, David R Kuhn, Ram D Sriram, Kevin G Brady
ISO/IEEE 11073 Personal Health Data (IEEE 11073 PHD) is a set of standards that addresses the interoperability of personal healthcare devices. As an important part of IEEE 11073 PHD, ISO/IEEE 1107-20601 optimized exchange protocol (IEEE 11073-20601) ...
5. Towards Ontology Evaluation across the Life Cycle
Fabian M. Neuhaus, Amanda Vizedom, Ken Baclawski, Mike Bennet, Mike Dean, Michael Denny, Michael Gruninger, Ali Hashemi, Terry Longstreth, Leo Obrst, Steven R. Ray, Ram D Sriram, Todd Schneider, Marcela Vegetti, Matthew West, Peter Yim
Currently, there is no agreed on methodology for development of ontologies, and there is no consensus on how ontologies should be evaluated. Consequently, evaluation techniques and tools are not widely utilized in the development of ontologies. This ...
6. Disassembly Process Information Model for Remanufacturing
Shaw C Feng, Hanmin Lee, Thomas Rollin Kramer, Che B. Joung, Parisa Ghodous, Ram D Sriram
The disassembly process is an essential activity performed on out-of-service products for remanufacturing. A disassembly process includes many subprocesses, such as separation, cleaning, repair, replacement, and inspection. The main purpose of perfor ...
7. Smart Networked Systems and Societies: Research Challenges
Ram D Sriram
We are witnessing a new revolution in computing and communication. The Internet, which has spanned several networks in a wide variety of domains, is having a significant impact on every aspect of our lives. The next generation of networks will utili ...
8. Testing the Nation‰s Health care Information Infrastructure
Kevin G Brady, Ram D Sriram, Bettijoyce B Lide, Kathleen M Roberts
According to a report by the Center for Medicare and Medicaid Services [CMS] (http://www.cms.gov), the United States spent nearly $2.6 trillion dollars on health care in 2010. It is estimated that this will nearly double by the end of this decade. T ...
9. Big Data Issues in Quantitative Imaging
Mary C Brady, Alden A Dima, Charles D. Fenimore, James J Filliben, John Lu, Adele P Peskin, Mala Ramaiah, Ganesh Saiprasad, Ram D Sriram
10. Monte Carlo and dynamics simulations of cdk5 Kinase inhibitor peptides p5 in aqueous solution
Antonio Cardone, Sergio Hassan, Mary C Brady, Ram D Sriram, Harish C. Pant
Protein function depends on shape changes that are triggered by interactions with other molecules.
Insights into protein dynamics and interactions enable the understanding of certain pathologies,
which may be caused by the deregulation of protein ...