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Author: laurie locascio
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1. Quantitative Measurements of the Size Scaling of Linear and Circular DNA in Nanofluidic Slitlike Confinement
Published: 2/14/2012
Authors: Elizabeth A Strychalski, Jon C Geist, Michael Gaitan, Laurie E Locascio, Samuel M Stavis
Abstract: Quantitative size measurements of single linear and circular DNA molecules in nanofluidic slitlike confinement are reported. A novel experimental method using DNA entropophoresis down a nanofluidic staircase implemented comprehensive variation of sl ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=908052

2. DNA Molecules Descending a Nanofluidic Staircase by Entropophoresis
Published: 1/26/2012
Authors: Samuel M Stavis, Jon C Geist, Michael Gaitan, Laurie E Locascio, Elizabeth A Strychalski
Abstract: A complex entropy gradient for confined DNA molecules was engineered for the first time. Following the second law of thermodynamics, this enabled the directed self-transport and self-concentration of DNA molecules. This new nanofluidic method is term ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=908034

3. A robust diffusion-based gradient generator for dynamic cell assays.
Published: 1/1/2012
Authors: Francisco Javier Atencia, Gregory A Cooksey, Laurie E Locascio
Abstract: This manuscript describes a new method to generate purely diffusive chemical gradients that can be modified in time. The device is simple in its design and easy to use, which makes it amenable to study biological processes that involve static or dy ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=909388

4. Stable nanoparticle aggregates/agglomerates of different sizes and the effect of their size on hemolytic cytotoxicity
Published: 12/1/2011
Authors: Justin M Zook, Robert I. MacCuspie, Laurie E Locascio, Michael W Halter, John T Elliott
Abstract: Methods to disperse nanoparticles reproducibly in aqueous solutions compatible with cell-based assays are critical for studying cytotoxicity. Here, we disperse gold and silver nanoparticles in cell culture media, letting them agglomerate to a variet ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=906154

5. DNA ENTROPOPHORESIS: A BALANCE OF ENTROPY AND DIFFUSION IN COMPLEX NANOCONFINEMENT
Published: 10/3/2011
Authors: Samuel M Stavis, Jon C Geist, Michael Gaitan, Laurie E Locascio, Elizabeth A Strychalski
Abstract: Entropophoresis ‹ motion caused by an entropy gradient ‹ is a novel nanofluidic method to direct the self-transport of biopolymers that established a new paradigm of nanofluidic functionality with broad relevance to lab-on-a-chip technol-ogy. He ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=909168

6. Art in Science
Published: 2/22/2011
Authors: Michael Gaitan, Laurie E Locascio
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=908028

7. Nanomaterial Toxicity: Emerging Standards and Efforts to Support Standards Development
Published: 2/1/2011
Authors: Laurie E Locascio, Vytautas Reipa, Justin M Zook, Richard C. Pleus
Abstract: For the first time in the history of industrialization, nanotechnology offers the unique opportunity to consider material safety ahead of its full implementation. Many scientists around the world have been motivated by this and are working on develo ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=905246

8. Entropophoresis of Single Biomolecules Down a Nanofluidic Staircase
Published: 1/11/2011
Authors: Samuel M Stavis, Elizabeth A Strychalski, Jon C Geist, Michael Gaitan, Laurie E Locascio
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=908403

9. On-chip CO2 control for microfluidic cell culture
Published: 1/1/2011
Authors: Samuel P Forry, Laurie E Locascio
Abstract: Carbon dioxide partial pressure (PCO2) was controlled on-chip by flowing pre-equilibrated aqueous solutions through control channels across the device. Elevated PCO2 (e.g. 0.05 atm) was modulated in neighboring stagnant channels via equilibration th ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=908449

10. Nanoslinky: DNA Entropophoresis Down a Nanofluidic Staircase
Published: 10/4/2010
Authors: Elizabeth A Strychalski, Laurie E Locascio, Samuel M Stavis, Michael Gaitan
Abstract: Almost all nanofluidic devices for biopolymer analysis have been limited by one or two confining structural dimen-sions or the application of external forces for biopolymer manipulation, which has restricted the scope of related lab-on-a-chip technol ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=906205



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