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Author: wyatt vreeland
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1. A Facile Route to the Synthesis of Monodisperse Nanoscale Liposomes Using 3D Microfluidic Hydrodynamic Focusing in a Concentric Capillary Array
Published: 5/14/2014
Authors: Wyatt N Vreeland, Renee R Hood, Don L. DeVoe, Francisco Javier Atencia, Donna M. Omiatek
Abstract: A novel microscale device has been developed to enable the one-step continuous flow assembly of monodisperse nanoscale liposomes using three-dimensional microfluidic hydrodynamic focusing (3D-MHF) in a radially symmetric capillary array. The 3D-M ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915562

2. A rapid, low-cost preparation of monodisperse niosomes in a microfluidic platform
Published: 6/1/2010
Authors: Catherine T. Lo, Andreas Jahn, Wyatt N Vreeland, Laurie E Locascio
Abstract: Niosomes are synthetic membrane vesicles made of self-assembled non-ionic surfactants (i.e. amphiphilic organic compounds). They bear the same properties as liposomes, namely having an aqueous interior that is separated from the exterior aqueous env ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=904028

3. Capillarity Induced Solvent?Actuated Bonding of Polymeric Microfluidic Devices
Published: 4/12/2006
Authors: Jayna J Shah, Jon C Geist, Laurie E Locascio, Michael Gaitan, Rao Mulpuri, Wyatt N Vreeland
Abstract: Rapid, robust and economical fabrication of fluidic microchannels is of fundamental importance for the successful development of disposable lab-on-a-chip devices. In this work, we present a solvent-actuated bonding method for fabricating polymeric th ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=32125

4. Chiral Separations by Temperature Gradient Focusing
Published: 2/1/2004
Authors: K M. Balss, Wyatt N Vreeland, Karen W Phinney, Michael J Tarlov, David J Ross
Abstract: Temperature gradient focusing (TGF) involves application of a temperature gradient across a microchannel or capillary. With an appropriate buffer, the temperature gradient creates a gradient in both the electric field and the electrophoretic velocity ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830871

5. Contactless Differential Conductivity Detection
Published: 10/12/2008
Authors: Gordon Allan Shaw, David J Ross, Steven Earl Fick, Wyatt N Vreeland
Abstract: We propose a new technique, contactless differential conductivity detection (CDCD,) to improve the detection limit of contactless conductivity detection for capillary and microchannel electrophoresis. By exploiting a 3-electrode differential configu ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=824689

6. Controlled Encapsulation of a Hydrophilic Drug Simulant in Nano-Liposomes Using Continuous Flow Microfluidics
Published: 6/4/2008
Authors: Andreas Jahn, Joseph Earl Reiner, Wyatt N Vreeland, Don DeVoe, Laurie E Locascio, Michael Gaitan
Abstract: A new method to tailor the size and size distribution of nanometer scale liposomes and control loading of liposomes with a model drug in a continuous-flow microfluidic design is presented. Size and size dispersion are determined with tandem Asymmetr ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=32987

7. Controlled Vesicle Self-Assembly in Continuous Two Phase Flow Microfluidic Channels
Published: 6/10/2004
Authors: Andreas Jahn, Wyatt N Vreeland, Laurie E Locascio, Michael Gaitan
Abstract: The spontaneous self-assembly of phospholipids into liposomes in aqueous solution results in the encapsulation of reagents into quantized packets in a manner that mimics cellular life-processes. Since their discovery in 1965, liposomes have been used ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=31518

8. Controlled Vesicle Self-Assembly in Microfluidic Channels with Hydrodynamic Focusing
Published: 12/18/2003
Authors: Andreas Jahn, Wyatt N Vreeland, Michael Gaitan, Laurie E Locascio
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=32726

9. Effects of temperature, acyl chain length, and flow-rate ratio on liposome formation and size in a microfluidic hydrodyanmic focusing device
Published: 3/21/2010
Authors: Justin M Zook, Wyatt N Vreeland
Abstract: Microfluidic hydrodynamic focusing of an alcohol/lipid mixture into a narrow fluid stream by two oblique buffer streams provides a controlled and reproducible method of forming phospholipid bilayer vesicles (i.e., liposomes) with relatively monodispe ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=903474

10. Liposome-Templated Supramolecular Assembly of Responsive Alginate Nanogels
Published: 3/14/2008
Authors: Jennifer S. Hong, Wyatt N Vreeland, Silvia H. De Paoli Lacerda, Laurie E Locascio, Michael Gaitan, Srinivasa R. Raghavan
Abstract: Nanosized gel particles (nanogels) are of interest for a variety of applications, including controlled release of drugs and single-molecule encapsulation. Here, we employ the cores of nanoscale liposomes as reaction vessels to template the assembly o ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=32779



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