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Author: wyatt vreeland
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1. Microfluidic Remote Loading for Rapid Single-Step Liposomal Drug Preparation
Published: 7/29/2014
Authors: Wyatt N Vreeland, Renee R Hood, Don L. DeVoe
Abstract: Here we report a microfluidic system that enables rapid and efficient remote loading of amphipathic drugs into nanoscale liposomes, combining liposome synthesis and remote drug loading in a continuous integrated process. Unlike established bulk m ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915563

2. A Facile Route to the Synthesis of Monodisperse Nanoscale Liposomes Using 3D Microfluidic Hydrodynamic Focusing in a Concentric Capillary Array
Published: 5/14/2014
Authors: Wyatt N Vreeland, Renee R Hood, Don L. DeVoe, Francisco Javier Atencia, Donna M. Omiatek
Abstract: A novel microscale device has been developed to enable the one-step continuous flow assembly of monodisperse nanoscale liposomes using three-dimensional microfluidic hydrodynamic focusing (3D-MHF) in a radially symmetric capillary array. The 3D-M ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915562

3. Microfluidic-Enabled of Liposomes Elucidate Size-Dependent Transdermal Transport
Published: 3/21/2014
Authors: Wyatt N Vreeland, Renee R Hood, Eric Kendall, Don L. DeVoe, Julia Finkel, Mariana Junqueira, Zenaide Quezado
Abstract: Microfluidic synthesis of small and nearly-monodisperse liposomes is used to investigate the size-dependent passive transdermal transport of nanoscale lipid vesicles. While large liposomes with diameters above 105 nm are found to be excluded from dee ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=915017

4. Microfluidic preparation of liposomes to determine particle size influence on cellular uptake mechanisms
Published: 10/3/2013
Authors: Wyatt N Vreeland, Abhay U Andar, Renee R Hood, Don L. DeVoe, Peter W Swaan
Abstract: Purpose: This study investigates the cellular uptake and trafficking of liposomes in Caco-2 cells, using vesicles with distinct average diameters ranging from 40 nm-276 nm. Liposomes were prepared by microfluidic hydrodynamic flow focusing, producing ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913538

5. Microfluidic Synthesis of Nano-Liposomal Anesthetics
Published: 5/12/2013
Authors: Wyatt N Vreeland, Renee R Hood, Eric Kendall, Mariana Junqueira, Julia Finkel, Don L. DeVoe
Abstract: Topical anesthesia has the ability to provide painless application of pain management medications for minor procedures such as venipuncture, particularly in the pediatric population. Liposomes have been proposed as a highly advantageous nanocarrier f ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=913770

6. A rapid, low-cost preparation of monodisperse niosomes in a microfluidic platform
Published: 6/1/2010
Authors: Catherine T. Lo, Andreas Jahn, Wyatt N Vreeland, Laurie E Locascio
Abstract: Niosomes are synthetic membrane vesicles made of self-assembled non-ionic surfactants (i.e. amphiphilic organic compounds). They bear the same properties as liposomes, namely having an aqueous interior that is separated from the exterior aqueous env ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=904028

7. Effects of temperature, acyl chain length, and flow-rate ratio on liposome formation and size in a microfluidic hydrodyanmic focusing device
Published: 3/21/2010
Authors: Justin M Zook, Wyatt N Vreeland
Abstract: Microfluidic hydrodynamic focusing of an alcohol/lipid mixture into a narrow fluid stream by two oblique buffer streams provides a controlled and reproducible method of forming phospholipid bilayer vesicles (i.e., liposomes) with relatively monodispe ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=903474

8. Magnetic connectors for microfluidic applications
Published: 1/1/2010
Authors: Francisco Javier Atencia, Gregory A Cooksey, Andreas Jahn, Justin M Zook, Wyatt N Vreeland, Laurie E Locascio
Abstract: We present a new type of connector based on a simple idea: using a ring magnet on one side of the microfluidic chip and a disc magnet on the other side to provide the interfacial force necessary to provide a sealed connection between tubing or needle ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=903395

9. The Proceedings of {mu}TAS 2008 Conference
Published: 11/20/2008
Authors: Laurie E Locascio, Michael Gaitan, Brian M. Paegel, David J Ross, Wyatt N Vreeland
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=901090

10. Unexpectedly High Entrapment Efficiency in Nanometer Scale Liposomes With Hydrodynamic Focusing Using Continuous-Flow Microfluidics
Published: 10/16/2008
Authors: Andreas Jahn, Joseph Earl Reiner, Wyatt N Vreeland, Don DeVoe, Laurie E Locascio, Michael Gaitan
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=33075



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