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Author: john kasianowicz
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11. Nanopore-based Single Molecule Determination of Polymer-cation Binding and Membrane Protein Dynamics
Joseph Earl Reiner, John J Kasianowicz, Joseph William Robertson
12. Theory for Polymer Analysis Using Nanopore-based Single-molecule Mass Spectrometry
Joseph Earl Reiner, John J Kasianowicz, Brian Joseph Nablo, Joseph William Robertson
Nanometer-scale pores have demonstrated potential as a tool for the electrical detection and characterization of molecules. To provide a physical basis for nanopore-based analytical metrology, we show that a simple model quantitatively describes how ...
13. Ultrasensitive Detection of Biowarfare Agents with Single Molecule Mass Spectrometry
Joseph William Robertson, John J Kasianowicz, Joseph Earl Reiner
14. Probing Single Nanometer-Scale Pores with Polymeric Molecular Rulers
Sarah E Henrickson, Edmund A DiMarzio, Qian Wang, Vincent M Stanford, John J Kasianowicz
It has been shown that individual molecules of single stranded DNA can be driven electrophoretically through a single Staphylococcus aureus ?-hemolysin ion channel. Polynucleotides thread through the channel as extended chains and the polymer-induced ...
15. On the electronic detection, characterization and quantification of biomarkers with single nanopores
John J Kasianowicz
16. Rectification of the Ionic Current through Carbon Nanotubes by Electrostatic Assembly of Polyelectrolytes
Neal R Scruggs, Joseph William Robertson, John J Kasianowicz, Kalman D Migler
Rectification of the ionic current flowing through nanotubes embedded in a polymeric membrane is achieved by selective adsorption of polycations to the nanotubes mouths. A one-dimensional model of ionic flux through a nanotube with charged entranc ...
17. Structure of Functional Staphylococcus aureus ¿-Hemolysin Channels in Tethered Bilayer Lipid Membranes
D. McGillivray, Gintaras Valincius, Frank Heinrich, Joseph William Robertson, David J. Vanderah, W. Febo-Ayala, I. Ignatjev, M. Losche, John J Kasianowicz
18. Sizing the Bacillus anthracis PA63 Channel with Nonelectrolyte Poly(ethylene glycols)
Brian Joseph Nablo, Kelly Halverson, Joseph William Robertson, Tam Nguyen, Rekha Panchal, Rick Gussio, Sina Bavari, Oleg V Krasilnikov, John J Kasianowicz
Non-electrolyte polymers of poly(ethylene glycol), PEG, were used to estimate the diameter of the ion channel formed by Bacillus anthracis protective antigen 63, PA63. Based on the ability of different molecular weight PEGs to partition into the pore ...
19. Nanoscopic Porous Sensors
John J Kasianowicz, Joseph William Robertson, Elaine Chan, Joseph Earl Reiner, Vincent M Stanford
There are thousands of different nanometer-scale pores in biology,many of which act as sensors for specific chemical agents. Recent work suggests that protein and solid-state nanopores have many potential uses in a wide variety of analytical applicat ...
20. Single molecule measurements within individual membrane-bound ion channels using a polymer-based bilayer lipid membrane chip
Louis P Hromada, Brian Joseph Nablo, Michael Gaitan, John J Kasianowicz, Don DeVoe
A polymer microfluidic platform for electrophysiological ion channel measurements is presented. The system includes an open-well bilayer lipid membrane formation site, integrated Ag/AgCl reference electrodes for on-chip electrical measurements, and m ...