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Author: pawel jaruga

Displaying records 41 to 50 of 62 records.
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41. Primary Fibroblasts of Cockayne Syndrome Patients Are Defective in Cellular Repair of 8-Hydroxyguanine and 8-Hydroxyadenine Resulting From Oxidative Stress
Published: 4/1/2003
Authors: J Tuo, Pawel Jaruga, H Rodriguez, V. Bohr, M Miral Dizdar
Abstract: Cockayne Syndrome (CS) is a genetic human disease with clinical symptoms that include neurodegeneration and premature aging. We show that primary fibroblasts from CS patients lack the ability to efficiently repair oxidative DNA damage. Primary fibr ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830324

42. Arabidopsis Thaliana Ogg1 Protein Excises 8-Hydroxyguanine and 2,6- Diamino-4-hydroxy-5-formamidopyrimidine from Oxidative Damaged DNA Containing Multiple Lesions
Published: 3/18/2003
Authors: T Morales-Ruiz, M Birincioglu, Pawel Jaruga, H Rodriguez, T. Roldan-Arjona, M Miral Dizdar
Abstract: A functional homologue of eukaryotic Ogg1 proteins in the model plant Arabidopsis thaliana has recently been cloned, isolated, and characterized [Garcia-Ortiz, M.V., Ariza, R.R., and Roldan-Arjona, T. (2001) Plant Mol. Biol. 47, 795-804]. This enzym ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830365

43. Biomarkers Used to Detect Genetic Damage in Tissue-Engineered Skin
Published: 1/1/2003
Authors: C D O'Connell, Peter E. Dr. Barker, M A Marino, P McAndrew, Donald H Atha, Pawel Jaruga, M Birincioglu, M. Dizdaroglu, H Rodriguez
Abstract: The goal of the research was to help identify cellular biomarkers and assess measurement technologies that will help manufacturers determine how cells react to inflammatory stimuli from different polymer matrixes and assure that tissue-engineered med ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830348

44. Oxidative DNA Damage Biomarkers Used in Tissue Engineered Skin
Published: 1/1/2003
Authors: H Rodriguez, Pawel Jaruga, M Birincioglu, Peter E. Dr. Barker, C D O'Connell, M. Dizdaroglu
Abstract: To assure that tissue engineered medical products are free of genetic changes that might occur from inflammation during the development phase of the product, our laboratory is responding to the need for test methods used to assess the safety and perf ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830346

45. Biomarkers of Oxidative DNA Damage in Tissue Engineered Skin Measured by LC/MS and GC/MS Technologies
Published: 9/1/2002
Authors: H Rodriguez, M Birincioglu, C D O'Connell, Peter E. Dr. Barker, Pawel Jaruga, M. Dizdaroglu
Abstract: Tissue engineering is an emerging area of biotechnology that will provide replacement tissues for patients, as well as complex, functional biological systems for research and testing in the pharmaceutical industry. Fundamentals to many tissue-engine ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830344

46. Biomarkers of TP53 Mutation and Y-Chromosome Loss Used to Detect Cellular/Genetic Damage in Tissue Engineered Skin
Published: 9/1/2002
Authors: H Rodriguez, M A Marino, P McAndrew, Donald H Atha, Pawel Jaruga, M Birincioglu, Peter E. Dr. Barker, C D O'Connell
Abstract: Tissue engineering is an emerging area of biotechnology that will provide replacement tissues for patients, as well as complex, functional biological systems for research and testing in the pharmaceutical industry. Fundamentals to many tissue-engine ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830349

47. The Cockayne Syndrome Group B Gene Product is Involved in Cellular Repair of 8-Hydroxyadenine in DNA
Published: 8/23/2002
Authors: J Tuo, Pawel Jaruga, H Rodriguez, M Miral Dizdar, V. Bohr
Abstract: Cockayne syndrome (CS) is a human disease characterized by sensitivity to sunlight, severe neurological abnormalities and accelerated aging. CS has two complementation groups, CS-A and CS-B. The CSB gene encodes the CSB protein with 1493 amino acid ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830310

48. Free Radical-Induced Damage to DNA: Mechanisms and Measurement
Published: 6/1/2002
Authors: M. Dizdaroglu, Pawel Jaruga, M Birincioglu, H Rodriguez
Abstract: Free radicals are produced in cells by cellular metabolism and by exogenous agents. These species react with biomolecules in cells including DNA. The resulting damage to DNA which is also called oxidative damage to DNA, is implicated in mutagenesis ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830270

49. Identification and Characterization of a Human DNA Glycosylase for Repair of Modified Bases in Oxidatively Damaged DNA
Published: 3/19/2002
Authors: T. K. Hazra, T. Izumi, I Boldough, B Imhoff, Y W Kow, Pawel Jaruga, M Miral Dizdar, Somenath Mitra
Abstract: 8-oxoguanine (8-oxoG), ring-opened purines (formamidopyrimidines or Fapys), and other oxidized DNA base lesions generated by reactive oxygen species, are often mutagenic and toxic, and have been implicated in the etiology of many diseases including c ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830581

50. Mass Spectrometric Assays for the Tandem Lesion 8,5'- Cyclo-2' Deoxyguanosine in Mammalian DNA
Published: 3/19/2002
Authors: Pawel Jaruga, M Birincioglu, H Rodriguez, M Miral Dizdar
Abstract: 8,5'-Cyclopurine-2'-deoxynucleosides are among major lesions in DNA that are formed by attack of hydroxyl radical. These compounds represent a concomitant damage to both sugar and base moieties of the same nucleoside and thus can be considered tandem ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830283



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