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Author: pawel jaruga

Displaying records 41 to 50 of 57 records.
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41. Biomarkers of TP53 Mutation and Y-Chromosome Loss Used to Detect Cellular/Genetic Damage in Tissue Engineered Skin
Published: 9/1/2002
Authors: H Rodriguez, M A Marino, P McAndrew, Donald H Atha, Pawel Jaruga, M Birincioglu, Peter E. Dr. Barker, C D O'Connell
Abstract: Tissue engineering is an emerging area of biotechnology that will provide replacement tissues for patients, as well as complex, functional biological systems for research and testing in the pharmaceutical industry. Fundamentals to many tissue-engine ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830349

42. The Cockayne Syndrome Group B Gene Product is Involved in Cellular Repair of 8-Hydroxyadenine in DNA
Published: 8/23/2002
Authors: J Tuo, Pawel Jaruga, H Rodriguez, M Miral Dizdar, V. Bohr
Abstract: Cockayne syndrome (CS) is a human disease characterized by sensitivity to sunlight, severe neurological abnormalities and accelerated aging. CS has two complementation groups, CS-A and CS-B. The CSB gene encodes the CSB protein with 1493 amino acid ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830310

43. Free Radical-Induced Damage to DNA: Mechanisms and Measurement
Published: 6/1/2002
Authors: M. Dizdaroglu, Pawel Jaruga, M Birincioglu, H Rodriguez
Abstract: Free radicals are produced in cells by cellular metabolism and by exogenous agents. These species react with biomolecules in cells including DNA. The resulting damage to DNA which is also called oxidative damage to DNA, is implicated in mutagenesis ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830270

44. Identification and Characterization of a Human DNA Glycosylase for Repair of Modified Bases in Oxidatively Damaged DNA
Published: 3/19/2002
Authors: T. K. Hazra, T. Izumi, I Boldough, B Imhoff, Y W Kow, Pawel Jaruga, M Miral Dizdar, Somenath Mitra
Abstract: 8-oxoguanine (8-oxoG), ring-opened purines (formamidopyrimidines or Fapys), and other oxidized DNA base lesions generated by reactive oxygen species, are often mutagenic and toxic, and have been implicated in the etiology of many diseases including c ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830581

45. Mass Spectrometric Assays for the Tandem Lesion 8,5'- Cyclo-2' Deoxyguanosine in Mammalian DNA
Published: 3/19/2002
Authors: Pawel Jaruga, M Birincioglu, H Rodriguez, M Miral Dizdar
Abstract: 8,5'-Cyclopurine-2'-deoxynucleosides are among major lesions in DNA that are formed by attack of hydroxyl radical. These compounds represent a concomitant damage to both sugar and base moieties of the same nucleoside and thus can be considered tandem ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830283

46. Chlorella Virus Pyrimidine Dimer Glycosylase Excises Ultraviolet Radiation- and Hydroxyl Radical-Induced Products 4,6-Diamino-5-Formamidopyrimidine and 2,6-Diamino-4-Hydroxy-5-Formamidopyrimidine from DNA
Published: 2/1/2002
Authors: Pawel Jaruga, R Jabil, Amanda K McCullough, H Rodriguez, M Miral Dizdar, R Stephen Lloyd
Abstract: A DNA glycosylase specific for UV radiation-induced pyrimidine dimers has been identified from chlorella virus Paramecium bursaria chlorella virus-1. This enzyme (Chlorella virus Pyrimidine dimer glycosylase [cv-pdgl) exhibits a 41% amino acid identi ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830227

47. Determination of Active Site Residues in Escherichia Coli Endonuclease VIII
Published: 1/25/2002
Authors: S. M. Burgess, Pawel Jaruga, M L Dodson, M Miral Dizdar, R Stephen Lloyd
Abstract: Endonuclease VIII from Escherichia coli is a DNA glycosylase/lyase that removes oxidatively damaged bases. EndoVIII is a functional homologue of endonuclease III, but a sequence homologue of formamidopyrimidine DNA glycosylase (Fpg). Using multiple ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830285

48. The Cockayne Syndrome Group B Gene Product is Involved in General Genome Base Excision Repair of 8-hydroxyguanine in DNA
Published: 12/7/2001
Authors: J Tuo, M Muftuoglu, C Chen, Pawel Jaruga, R R Selzer, R M Brosh, H Rodriguez, M Miral Dizdar, V. Bohr
Abstract: Cockayne Syndrome (CS) is a human genetic disorder with two complementation groups, CS-A and CS-B. The CSB gene product is involved in transcription-coupled repair of DNA damage but may participate in other pathways of DNA metabolism. The present s ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830260

49. Measurement of 8-Hydroxy-2'-Deoxyadenosine In DNA by Liquid Chromatography/Mass Spectrometry
Published: 8/1/2001
Authors: Pawel Jaruga, H Rodriguez, M Miral Dizdar
Abstract: 8-Hydroxyadenine (8-OH-Ade) is one of the major lesions, which is formed in DNA by hydroxyl radical attack on the C-8 position of adenine followed by oxidation. We describe the measurement of the nucleoside form of this compound, 8-hydroxy-2'-deoxyad ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830242

50. Identification and Quantification of 8,5'-Cyclo-2'-Deoxyadenosine in DNA by Liquid Chromatography/Mass Spectrometry
Published: 4/1/2001
Authors: M. Dizdaroglu, Pawel Jaruga, H Rodriguez
Abstract: Recent studies suggested that 8,5'-cyclo-2'-deoxyadenosine may play a role in diseases with defective nucleotide-excision repair. This compound is one of the major lesions formed in DNA by hydroxyl radical attack on sugar moiety of 2'-deoxyadenosine ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830211



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