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Author: pawel jaruga

Displaying records 31 to 40 of 57 records.
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31. Overexpression and rapid purification of Escherichia coli formamidopyrimidine-DNA glycosylase.
Published: 3/1/2004
Authors: Prasad T Reddy, Pawel Jaruga, T O'Connor, H Rodriguez, M Dizdaroglu
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=903185

32. A Comparative Study of Biomarkers of Oxidative DNA Damage Used to Detect Free Radical Damage in Tissue-Engineered Skin
Published: 1/1/2004
Authors: H Rodriguez, Pawel Jaruga, M Birincioglu, Peter E. Dr. Barker, C D O'Connell, M. Dizdaroglu
Abstract: The process of tissue engineering often involves the mixing of cells with polymers that may cause inflammation to the tissue and thus elevate the level of endogenous free radical production. In order to assure that such composite materials are free ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830345

33. Molecular Biomarkers Used to Detect Cellular/Genetic Damage in Tissue-Engineered Skin
Published: 1/1/2004
Authors: C D O'Connell, Peter E. Dr. Barker, M A Marino, P McAndrew, Donald H Atha, Pawel Jaruga, M Birincioglu, H Rodriguez
Abstract: To assure that tissue engineered medical products are free of genetic changes that might occur from inflammation during the development phase of the product, Tissue engineered skin (TestSkin II) was obtained, separated into its two cellular layers (e ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830578

34. DNA Base Damage by the Antitumor Agent 3-Amino-1,2,4-Benzotriazine 1,4-Dioxide (Tirapazamine)
Published: 9/24/2003
Authors: M Birincioglu, Pawel Jaruga, G Chowdhury, H Rodriguez, M Miral Dizdar, K Gates
Abstract: Tirapazamine is a bioreductively activated DNA-damaging agent that selectively kills the hypoxic cells found in solid tomors. This compound shows great clinical promise and is currently being examined in a variety of clinical trails, including sever ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830363

35. Genomic DNA of Nostoc Commune (Cyanobacteria) Becomes Covalently Modified During Long-Term (Decades) Desiccation But Is Protected From Oxidative Damage and Degradation
Published: 6/15/2003
Authors: B Shirkey, N J McMaster, Sue C Smith, D J Wright, H Rodriguez, Pawel Jaruga, M Birincioglu, R F Helm, M Potts
Abstract: Genomic DNA of Nostoc commume (Cyanobacteria) became covalently modified during decades of desiccation. Amplification of gene loci from desiccated cells required pretreatment of DNA with N-phenacylthiazolium bromide; a reagent that cleaves DNA- and ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830392

36. Primary Fibroblasts of Cockayne Syndrome Patients Are Defective in Cellular Repair of 8-Hydroxyguanine and 8-Hydroxyadenine Resulting From Oxidative Stress
Published: 4/1/2003
Authors: J Tuo, Pawel Jaruga, H Rodriguez, V. Bohr, M Miral Dizdar
Abstract: Cockayne Syndrome (CS) is a genetic human disease with clinical symptoms that include neurodegeneration and premature aging. We show that primary fibroblasts from CS patients lack the ability to efficiently repair oxidative DNA damage. Primary fibr ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830324

37. Arabidopsis Thaliana Ogg1 Protein Excises 8-Hydroxyguanine and 2,6- Diamino-4-hydroxy-5-formamidopyrimidine from Oxidative Damaged DNA Containing Multiple Lesions
Published: 3/18/2003
Authors: T Morales-Ruiz, M Birincioglu, Pawel Jaruga, H Rodriguez, T. Roldan-Arjona, M Miral Dizdar
Abstract: A functional homologue of eukaryotic Ogg1 proteins in the model plant Arabidopsis thaliana has recently been cloned, isolated, and characterized [Garcia-Ortiz, M.V., Ariza, R.R., and Roldan-Arjona, T. (2001) Plant Mol. Biol. 47, 795-804]. This enzym ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830365

38. Biomarkers Used to Detect Genetic Damage in Tissue-Engineered Skin
Published: 1/1/2003
Authors: C D O'Connell, Peter E. Dr. Barker, M A Marino, P McAndrew, Donald H Atha, Pawel Jaruga, M Birincioglu, M. Dizdaroglu, H Rodriguez
Abstract: The goal of the research was to help identify cellular biomarkers and assess measurement technologies that will help manufacturers determine how cells react to inflammatory stimuli from different polymer matrixes and assure that tissue-engineered med ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830348

39. Oxidative DNA Damage Biomarkers Used in Tissue Engineered Skin
Published: 1/1/2003
Authors: H Rodriguez, Pawel Jaruga, M Birincioglu, Peter E. Dr. Barker, C D O'Connell, M. Dizdaroglu
Abstract: To assure that tissue engineered medical products are free of genetic changes that might occur from inflammation during the development phase of the product, our laboratory is responding to the need for test methods used to assess the safety and perf ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830346

40. Biomarkers of Oxidative DNA Damage in Tissue Engineered Skin Measured by LC/MS and GC/MS Technologies
Published: 9/1/2002
Authors: H Rodriguez, M Birincioglu, C D O'Connell, Peter E. Dr. Barker, Pawel Jaruga, M. Dizdaroglu
Abstract: Tissue engineering is an emerging area of biotechnology that will provide replacement tissues for patients, as well as complex, functional biological systems for research and testing in the pharmaceutical industry. Fundamentals to many tissue-engine ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830344



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