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Author: pawel jaruga

Displaying records 31 to 40 of 61 records.
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31. Structural alterations in breast stromal and epithelial DNA: the influence of 8,5'-cyclo-2'-deoxyadenosine
Published: 6/1/2006
Authors: K. M. Anderson, Pawel Jaruga, C. R. Ramsey, N. K. Gilman, V. M. Green, S. W. Rostad, J. T. Emerman, M Miral Dizdar, D. C. Malins
Abstract: (5'S)-8,5'-Cyclo-2'-deoxyadenosine (S-cdA), which arises from the reaction of the hydroxyl radical (*OH) with 2'-deoxyadenosine in DNA, is a lesion comprising a base-sugar linkage that distorts the DNA backbone. This structure impedes transcription a ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=907940

32. Repair of Formamidopyrimidines in DNA Involves Different Glycosylases - Role of the OGG1, NTH1, and NEIL1 Enzymes
Published: 12/9/2005
Authors: J Hu, N de Souza-Pinto, K Haraguchi, Barbara A Hogue, Pawel Jaruga, M M Greenberg, M Miral Dizdar, V. Bohr
Abstract: 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) and 4,6-diamino-5-formamidopyrimidine (FapyA), are formed abundantly in DNA of cultured cells or tissues exposed to ionizing radiation or to other free radical-generating systems. We show here that ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830498

33. Mouse NEIL1 protein is specific for excision of 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine from oxidatively damaged DNA
Published: 12/21/2004
Authors: Pawel Jaruga, M Birincioglu, T A Rosenquist, M Miral Dizdar
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=903209

34. Overexpression and Rapid Purification of Escherichia Coli Formamidopyrimidine-DNA Glycosylase
Published: 3/1/2004
Authors: Prasad T Reddy, Pawel Jaruga, T R O'Connor, H Rodriguez, M Miral Dizdar
Abstract: Formamidopyrimidine DNA glycosylase (Fpg) is a DNA glycosylase with an associated AP lyase activity. As a DNA repair enzyme, Fpg excises several modified bases from DNA associated with exposure to oxidizing agents such as free radicals. Experiments ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830402

35. Overexpression and rapid purification of Escherichia coli formamidopyrimidine-DNA glycosylase.
Published: 3/1/2004
Authors: Prasad T Reddy, Pawel Jaruga, T O'Connor, H Rodriguez, M Dizdaroglu
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=903185

36. A Comparative Study of Biomarkers of Oxidative DNA Damage Used to Detect Free Radical Damage in Tissue-Engineered Skin
Published: 1/1/2004
Authors: H Rodriguez, Pawel Jaruga, M Birincioglu, Peter E. Dr. Barker, C D O'Connell, M. Dizdaroglu
Abstract: The process of tissue engineering often involves the mixing of cells with polymers that may cause inflammation to the tissue and thus elevate the level of endogenous free radical production. In order to assure that such composite materials are free ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830345

37. Molecular Biomarkers Used to Detect Cellular/Genetic Damage in Tissue-Engineered Skin
Published: 1/1/2004
Authors: C D O'Connell, Peter E. Dr. Barker, M A Marino, P McAndrew, Donald H Atha, Pawel Jaruga, M Birincioglu, H Rodriguez
Abstract: To assure that tissue engineered medical products are free of genetic changes that might occur from inflammation during the development phase of the product, Tissue engineered skin (TestSkin II) was obtained, separated into its two cellular layers (e ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830578

38. DNA Base Damage by the Antitumor Agent 3-Amino-1,2,4-Benzotriazine 1,4-Dioxide (Tirapazamine)
Published: 9/24/2003
Authors: M Birincioglu, Pawel Jaruga, G Chowdhury, H Rodriguez, M Miral Dizdar, K Gates
Abstract: Tirapazamine is a bioreductively activated DNA-damaging agent that selectively kills the hypoxic cells found in solid tomors. This compound shows great clinical promise and is currently being examined in a variety of clinical trails, including sever ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830363

39. Genomic DNA of Nostoc Commune (Cyanobacteria) Becomes Covalently Modified During Long-Term (Decades) Desiccation But Is Protected From Oxidative Damage and Degradation
Published: 6/15/2003
Authors: B Shirkey, N J McMaster, Sue C Smith, D J Wright, H Rodriguez, Pawel Jaruga, M Birincioglu, R F Helm, M Potts
Abstract: Genomic DNA of Nostoc commume (Cyanobacteria) became covalently modified during decades of desiccation. Amplification of gene loci from desiccated cells required pretreatment of DNA with N-phenacylthiazolium bromide; a reagent that cleaves DNA- and ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830392

40. Primary Fibroblasts of Cockayne Syndrome Patients Are Defective in Cellular Repair of 8-Hydroxyguanine and 8-Hydroxyadenine Resulting From Oxidative Stress
Published: 4/1/2003
Authors: J Tuo, Pawel Jaruga, H Rodriguez, V. Bohr, M Miral Dizdar
Abstract: Cockayne Syndrome (CS) is a genetic human disease with clinical symptoms that include neurodegeneration and premature aging. We show that primary fibroblasts from CS patients lack the ability to efficiently repair oxidative DNA damage. Primary fibr ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=830324



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