You searched on: Author: pawel jaruga
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21. The oxidative DNA glycosylases of Mycobacterium tuberculosis exhibit different substrate specificities from their Escherichia coli counterparts
Yin Guo, Viswanath Bandaru, Pawel Jaruga, Xiaobei Zhao, Cynthia Burrows, Shigenori Iwai, M Miral Dizdar, Jeffrey Bond, Susan Wallace
The DNA glycosylases function in the first step of the base excision repair process that is responsible for removing endogenous oxidative purine and pyrimidine damages from DNA. The DNA glycosylases that remove oxidized DNA bases fall into two genera ...
22. Substrate specificity and excision kinetics of natural polymorphic variants and phosphomimetic mutants of human 8-oxoguanine-DNA glycosylase
Viktoriya Sidorenko, Arthur P Grollman, Pawel Jaruga, M Miral Dizdar, Dmitry Zharhov
Human 8-oxoguanine-DNA-glycosylase (OGG1) efficiently removes mutagenic 8-oxoguanine (8-oxoGua) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) when paired with cytosine in damaged DNA. Excision of 8-oxoGua mispaired with adenine may lead t ...
23. Glutathione Depletion by Buthionine Sulfoximine Induces Oxidative Damage to DNA in Organs of Rabbits in vivo
Goksel Gokce, Gonen Ozsarlak, Gulgun Oktay, Guldal Kirkali, Pawel Jaruga, M Miral Dizdar, Zeliha Kerry
Glutathione (GSH) exists in mammalian tissues in vivo at high concentrations and plays an important protective role against oxidatively induced damage to biological molecules including DNA. We investigated oxidatively induced damage to DNA by GSH dep ...
24. Plant and fungal Fpg homologs are formamidopyrimidine DNA glycosylases but not 8-oxoguanine DNA glycosylases
Scott D Kathe, Ramiro Barrantes-Reynolds, Pawel Jaruga, Michael Newton, Cynthia Burrows, Viswanath Bandaru, M Miral Dizdar, Jeffrey Bond, Susan Wallace
Formamidopyrimidine DNA glycosylase (Fpg) and endonuclease VIII (Nei) share an overall common three dimensional structure and primary amino acid sequence in conserved structural motifs but have different substrate specificities, with bacterial Fpg pr ...
25. Accumulation of (5'S)-8,5'-cyclo-2'-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice
Guldal Kirkali, N de Souza-Pinto, Pawel Jaruga, V. Bohr, M Miral Dizdar
Cockayne syndrome (CS) is a human genetic disorder characterized by sensitivity to UV radiation, neurodegeneration, premature aging among other phenotypes. CS complementary group B (CS-B) gene (csb) encodes the CSB protein (CSB) that is involved in b ...
26. Measurement of formamidopyrimidines in DNA
Pawel Jaruga, Guldal Kirkali, M Miral Dizdar
Formamidopyrimidines, 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua), are among major lesions in DNA generated by hydroxyl radical attack, UV radiation or photosensitization in vitro and in vivo. ...
27. Human Polymorphic Variants of the NEIL1 DNA Glycosylase: Potential Implications for Human Health
Laura Roy, Pawel Jaruga, Thomas Wood, Amanda K McCullough, M Miral Dizdar, R. Stephen Lloyd
In mammalian cells, the repair of DNA bases damaged by reactive oxygen species is primarily initiated by a series of DNA glycosylases that include OGG1, NTH1, NEIL1 and NEIL2. To explore the functional significance of NEIL1, we recently reported tha ...
28. Reduced repair of 8-hydroxyguanine in the human breast cancer cell line, HCC1937
S. G. Nyaga, A. Lohani, Pawel Jaruga, A. Trzeciak, M Miral Dizdar, M. K. Evans
29. Molecular Analysis of Base Damage Clustering Associated with a Site-Specific Radiation-Induced DNA Double-Strand Break
K. Datta, Pawel Jaruga, M Miral Dizdar, R. D. Newmann, T. A. Winters
30. New functions of XPC in the protection of human skin cells from oxidative damage
M. D'Errico, E. Parlanti, M. Teson, B. M. Bernardes de Jesus, P. Degan, A. Calcagnile, Pawel Jaruga, M. Bjoras, M. Crescenzi, A. M. Pedrini, J.-M. Egly, G. Zambruno, M. Stefanini, M Miral Dizdar, E. Dogliotti