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Author: pawel jaruga

Displaying records 11 to 20 of 57 records.
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11. A Major Role for Non-Enzymatic Antioxidant Processes in the Radioresistance of Halobacterium salinarum
Published: 4/1/2011
Authors: M Miral Dizdar, Pawel Jaruga, Courtney K Robinson, Kim Webb, Amardeep Kaur, Nitin S Baliga, Allen Place, Jocelyne DiRuggiero
Abstract: Oxidative stress occurs when the generation of reactive oxygen species (ROS) exceeds the capacity of the cell‰s endogenous systems to neutralize them. We analyzed the oxidative stress responses and cellular damage of the archaeon Halobacterium salina ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=907681

12. Identification and quantification of (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines in human urine as putative biomarkers of oxidatively induced damage to DNA
Published: 6/18/2010
Authors: Pawel Jaruga, M Miral Dizdar
Abstract: Oxidatively induced DNA damage occurs in living organisms by endogenous and exogenous sources, and is implicated in a variety of disease processes including carcinogenesis and aging. Therefore, biomarkers of oxidatively induced DNA damage are of grea ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=905140

13. The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo
Published: 3/16/2010
Authors: Minin Liu, Viswanath Bandaru, Jeffrey Bond, Pawel Jaruga, Xiaobei Zhao, Plamen P Christov, Cynthia Burrows, Carmelo J. Rizzo, M Miral Dizdar, Susan Wallace
Abstract: To protect cells from oxidative DNA damage and mutagenesis, organisms possess multiple glycosylases to recognize the damaged bases and to initiate the Base Excision Repair (BER) pathway. Recently, three DNA glycosylases were identified in mammals tha ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=903370

14. Evidence for the involvement of DNA repair enzyme NEIL1 in nucleotide excision repair of (5'R)- and (5'S)-8,5'-Cyclo-2'-deoxyadenosines
Published: 2/16/2010
Authors: Pawel Jaruga, Yan Xiao, Vladimir Vartanian, R Stephen Lloyd, M Miral Dizdar
Abstract: The DNA repair enzyme NEIL1 is a DNA glycosylase that is involved in the first step of base excision repair (BER) of oxidatively induced DNA damage. NEIL1 exhibits a strong preference for excision of 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2, ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=904755

15. The oxidative DNA glycosylases of Mycobacterium tuberculosis exhibit different substrate specificities from their Escherichia coli counterparts
Published: 2/4/2010
Authors: Yin Guo, Viswanath Bandaru, Pawel Jaruga, Xiaobei Zhao, Cynthia Burrows, Shigenori Iwai, M Miral Dizdar, Jeffrey Bond, Susan Wallace
Abstract: The DNA glycosylases function in the first step of the base excision repair process that is responsible for removing endogenous oxidative purine and pyrimidine damages from DNA. The DNA glycosylases that remove oxidized DNA bases fall into two genera ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=904173

16. Substrate specificity and excision kinetics of natural polymorphic variants and phosphomimetic mutants of human 8-oxoguanine-DNA glycosylase
Published: 9/1/2009
Authors: Viktoriya Sidorenko, Arthur P Grollman, Pawel Jaruga, M Miral Dizdar, Dmitry Zharhov
Abstract: Human 8-oxoguanine-DNA-glycosylase (OGG1) efficiently removes mutagenic 8-oxoguanine (8-oxoGua) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) when paired with cytosine in damaged DNA. Excision of 8-oxoGua mispaired with adenine may lead t ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=902113

17. Glutathione Depletion by Buthionine Sulfoximine Induces Oxidative Damage to DNA in Organs of Rabbits in vivo
Report Number: 901398
Published: 6/9/2009
Authors: Goksel Gokce, Gonen Ozsarlak, Gulgun Oktay, Guldal Kirkali, Pawel Jaruga, M Miral Dizdar, Zeliha Kerry
Abstract: Glutathione (GSH) exists in mammalian tissues in vivo at high concentrations and plays an important protective role against oxidatively induced damage to biological molecules including DNA. We investigated oxidatively induced damage to DNA by GSH dep ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=901398

18. Plant and fungal Fpg homologs are formamidopyrimidine DNA glycosylases but not 8-oxoguanine DNA glycosylases
Published: 5/1/2009
Authors: Scott D Kathe, Ramiro Barrantes-Reynolds, Pawel Jaruga, Michael Newton, Cynthia Burrows, Viswanath Bandaru, M Miral Dizdar, Jeffrey Bond, Susan Wallace
Abstract: Formamidopyrimidine DNA glycosylase (Fpg) and endonuclease VIII (Nei) share an overall common three dimensional structure and primary amino acid sequence in conserved structural motifs but have different substrate specificities, with bacterial Fpg pr ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=900972

19. Accumulation of (5'S)-8,5'-cyclo-2'-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice
Published: 2/1/2009
Authors: Guldal Kirkali, N de Souza-Pinto, Pawel Jaruga, V. Bohr, M Miral Dizdar
Abstract: Cockayne syndrome (CS) is a human genetic disorder characterized by sensitivity to UV radiation, neurodegeneration, premature aging among other phenotypes. CS complementary group B (CS-B) gene (csb) encodes the CSB protein (CSB) that is involved in b ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=832387

20. Measurement of formamidopyrimidines in DNA
Published: 12/15/2008
Authors: Pawel Jaruga, Guldal Kirkali, M Miral Dizdar
Abstract: Formamidopyrimidines, 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua), are among major lesions in DNA generated by hydroxyl radical attack, UV radiation or photosensitization in vitro and in vivo. ...
http://www.nist.gov/manuscript-publication-search.cfm?pub_id=832358



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